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Linzess (Linaclotide) is a prescription drug that is used to help treat the symptoms of bowel problems, such as irritable bowel syndrome with constipation and chronic constipation in adults. This medication helps to increase the amount of fluid found in the intestines that helps to move food more quickly through the bowel.
Linzess: An Overview
This medication helps to relieve pain by blocking the signals relating to pain within the bowels. Linaclotide is a guanylate cyclase type C (GC-C) agonist and for those suffering from irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation it helps reducing straining during bowel movements and associated pain and bloating. It is important to not that Linaclotide is not a cure for the condition, it simply helps manage the symptoms.
The active medicinal ingredient in Linzess is Linaclotide, which is manufactured by Allergan. In Canada and in the United Kingdom, Linzess is also marketed under the trade name Constella.
Linzess is available in the following dosage forms: 72mcg, 145mcg, and 290mcg. The 72mcg, 145mcg, and 290mcg capsules are white color imprinted with "FL 72", "FL 145", and "FL 290" respectively.
There is no Linzess generic versions currently available on the market.
To place an order to buy Linzess an order can be placed online, over the phone, and even conveniently through our online Pharmacy chat. The maximum amount that can be ordered is a 3-month supply of medication.
Linzess Cost and Coupon Information
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Linzess (Linaclotide) Medication Information
Your healthcare provider may prescribe Linzess to treat Irritable Bowel Syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). In both of these conditions, a person has difficulty passing normal bowel movements. Bowel movements may be irregular, inconsistent, and painful.
Linzess works by pulling the electrolytes chloride and bicarbonate from the inside of intestinal cells into the empty space of the intestines. By pulling electrolytes into the intestines, Linzess promotes fluid movement, which softens the stool and increases transit in the gastrointestinal tract. Linzess also helps to treat pain associated with constipation.
Your doctor will prescribe a dose based on which condition you are treating.
For IBS-C, the correct dose is 290 mcg by mouth once daily, 30 minutes before the first meal of the day.
For CIC, the correct dose ranges from 72-145 mcg by mouth once daily, 30 minutes before the first meal of the day.
The most common effect of Linzess is severe diarrhea. Call your doctor if severe diarrhea occurs. You may need to pause the medication.
Other common side effects include:
- Abdominal distension
- Abdominal pain
- Fecal incontinence
- Severe diarrhea
- Upper respiratory tract infection
- Viral gastroenteritis
Linzess is contraindicated in people who are younger than six years of age.
Linzess should be avoided in people between the ages of 6 and 18.
Linzess should be used with caution in people who are younger than 18 years of age.
Do not use Linzess if you have a history of bowel blockage.
There are no known significant drug-drug interactions with Linzess.
Keep Linzess in the original container. It should not be repackaged or put into a new bottle. The bottle should be kept out of rooms with high moisture levels, like the kitchen or bathroom. Leave the desiccant in the container and do not remove it after opening.
Store Linzess at room temperature, approximately 25°C (77°F) and within the range of 15°C to 30°C
- Tell your doctor if you are pregnant or planning to become pregnant when you start Linzess.
- Go to the emergency room if you develop new abdominal pain or experience bright red, bloody stools.
- Linzess must be kept away from moisture and left in its original container.
What should I do if I miss a dose of Linzess?
Take the next dose at your regular time. Do not take two doses at the same time.
What if I am having trouble swallowing the capsule?
The capsules can be opened and mixed with either a teaspoon of applesauce or 30 milliliters of water. Do not crush or chew the capsules.
Do I need to take Linzess during a certain time of the day?
Yes, Linzess should be taken 30 minutes before the first meal of the day. Take it on an empty stomach.
- Linzess [package insert]. Cambridge, MA: Allergan; 2017.
Author: Dr. Conor Sheehy, PharmD, BCPS
Dr. Sheehy is a board-certified pharmacotherapy specialist. He has worked in multiple practice settings, including retail and hospital pharmacies, and in medical clinics. He specializes in anticoagulation, psychiatric medications, and diabetes medications. He strives to empower his patients to understand their medications and improve their overall medical care.
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.