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Entresto (Sacubitril/Valsartan) – Product Information
Entresto is a prescription medication that is used to lessen the risk of cardiovascular death. People taking it are not highly likely to get hospitalized for Class II and Class IV heart failure.
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This medication is manufactured by Novartis, and we carry it in these dosages: 24mg/26mg, 49mg/51mg and 97mg/103mg. There are two active medicinal ingredients are sacubitril and valsartan. We offer this medication from both Canada and the United Kingdom. The shipping time would be 7 to 10 business days from when the dispensing pharmacy fills the order.
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Entresto (Sacubitril and Valsartan) Medication Information
Entresto contains the medications valsartan and sacubitril. It is prescribed for people with heart failure and reduces the risk of death and hospitalization from cardiac events like heart attack and stroke. If you use Entresto, you should be taking it with other heart medications prescribed by your doctor.
The first active ingredient is sacubitril, which is a neprilysin inhibitor. Neprilysin breaks down certain protein molecules in the kidneys, and these molecules help protect the kidneys and heart.
The second active ingredient is valsartan, an angiotensin II receptor blocker (ARB) that is used to treat high blood pressure when prescribed on its own. In combination with sacubitril, valsartan works in heart failure by decreasing the stress on the heart.
Entresto comes in the following dosage forms:
- Sacubitril/Valsartan 24/26 mg
- Sacubitril/Valsartan 49/51 mg
- Sacubitril/Valsartan 93/103 mg
The normal starting dose is one tablet of Entresto 24/26 mg by mouth twice daily. After two to four weeks, the dose may be increased to Entresto 49/51 mg by mouth twice daily. After another two to four weeks, the dose may be increased again to Entresto 97/103 mg twice daily.
Take Entresto with or without food.
- Decreased hematocrit
- Decreased hemoglobin
- High blood potassium
- Increase blood creatinine
- Kidney failure
- Low blood pressure
If you were taking an ACE inhibitor before starting Entresto, you should stop the ACE inhibitor and wait at least 36 hours before starting Entresto. Examples of ACE inhibitors include:
If you have diabetes, do not take Tekturna (aliskiren) and Entresto together.
If you have taken an ACE inhibitor or ARB in the past and experienced swelling under the skin, you should not take Entresto.
Common drug interactions with Entresto may include:
- ACE inhibitors
- Sodium phosphates
Store Entresto at controlled room temperature between 20°C to 25°C (77°F). Keep Entresto out of rooms with high moisture like the bathroom or kitchen.
- Take Entresto twice daily with or without food.
- Entresto is harmful to a developing fetus. If you are taking Entresto, tell your doctor immediately.
- If you miss a dose of Entresto, take it as soon as you remember if it’s within eight hours. If it’s later than eight hours, do not double up, and take your next dose at the regular time.
Can I take Entresto if I have impaired kidney function?
Yes, in most cases, but it depends on your kidney function. Speak with your doctor about your current kidney function and whether you can continue Entresto or if you should lower the dose.
How long do I need to take Entresto?
It should be taken lifelong unless directed by your doctor.
What should I do if I get dizzy while taking Entresto?
Dizziness may be a sign of low blood pressure. Sit or stand slowly and take your blood pressure as soon as you have the chance.
- Entresto [package insert]. East Hanover, NJ: Novartis; 2019.
Author: Dr. Conor Sheehy, PharmD, BCPS
Dr. Sheehy is a board-certified pharmacotherapy specialist. He has worked in multiple practice settings, including retail and hospital pharmacies, and in medical clinics. He specializes in anticoagulation, psychiatric medications, and diabetes medications. He strives to empower his patients to understand their medications and improve their overall medical care.
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.