Cardizem CD (Diltiazem CD)

(℞) Prescription Required

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Cardizem CD 300mg

Product of United Kingdom
Manufactured by: Napp Pharmaceuticals
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Cardizem CD is also marketed under the name Adizem XL
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Cardizem CD 300mg
Product of United Kingdom
Manufactured by Napp Pharmaceuticals
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Cardizem CD 240mg

Product of New Zealand
Manufactured by: Sanofi Aventis
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Cardizem CD 240mg
Product of New Zealand
Manufactured by Sanofi Aventis
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Cardizem CD 360mg

Product of Australia
Manufactured by: Sanofi Aventis
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Cardizem CD 360mg
Product of Australia
Manufactured by Sanofi Aventis
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Diltiazem CD 120mg

Product of Canada
Manufactured by: Apotex Inc
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Diltiazem CD 120mg
Product of Canada
Manufactured by Apotex Inc
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Diltiazem CD 180mg

Product of Canada
Manufactured by: Apotex Inc
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Diltiazem CD 180mg
Product of Canada
Manufactured by Apotex Inc
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Diltiazem CD 240mg

Product of Canada
Manufactured by: Apotex Inc
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Diltiazem CD 240mg
Product of Canada
Manufactured by Apotex Inc
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Ditiazem CD 300mg

Product of Canada
Manufactured by: Cobalt Pharmaceuticals Inc
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Ditiazem CD 300mg
Product of Canada
Manufactured by Cobalt Pharmaceuticals Inc
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Cardizem CD 180mg

Product of Australia
Manufactured by: Sanofi Aventis
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Cardizem CD 180mg
Product of Australia
Manufactured by Sanofi Aventis
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Cardizem CD 360mg

Product of New Zealand
Manufactured by: Sanofi Aventis
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Cardizem CD 360mg
Product of New Zealand
Manufactured by Sanofi Aventis
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Cardizem CD (Diltiazem) Medication Information

Uses

Cardizem CD is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive medications. Cardizem CD is indicated for the management of chronic stable angina and angina due to coronary artery spasm.

Dosage

There are oral capsules available in several different strengths:

  • 120 mg
  • 180 mg
  • 240 mg
  • 300 mg
  • 360 mg

Side Effects

The most common side effects of Cardizem include:

  • Headache
  • Dizziness
  • Bradycardia
  • AV block
  • Edema
  • ECG abnormality
  • Asthenia

Speak with your doctor or pharmacist for a full list of side effects that applies to you.

Precautions

Cardizem (diltiazem hydrochloride) is extensively metabolized by the liver and excreted by the kidneys and in bile. As with any drug given over prolonged periods, laboratory parameters of renal and hepatic function should be monitored at regular intervals. The drug should be used with caution in patients with impaired renal or hepatic function.

Dermatological events may be transient and may disappear despite continued use of Cardizem. However, skin eruptions progressing to erythema multiforme and/or exfoliative dermatitis have also been infrequently reported. Should a dermatologic reaction persist, the drug should be discontinued.

Interactions

Some of the common drug interactions with Cardizem:

  • Anesthetics
  • Benzodiazepines
  • Beta-blockers
  • Buspirone
  • Carbamazepine
  • Cimetidine
  • Clonidine
  • Cyclosporine
  • Digoxin
  • Quinidine
  • Rifampin
  • Statins

Speak with your doctor or pharmacist for more information. 

Storage

Store at controlled room temperature (59º–86ºF). Avoid excessive humidity.

Pharmacist Tips

  • Patients controlled on diltiazem alone or in combination with other medications may be switched to Cardizem CD capsules at the nearest equivalent total daily dose.
  • Subsequent titration to higher or lower doses may be necessary and should be initiated as clinically warranted.
  • The incidence of side effects increases as the dose increases with first degree AV block, dizziness, and sinus bradycardia bearing the strongest relationship to dose

Diltiazem CD FAQs

Can I take this with food?

Can be taken with or without food.

 

Can I take this if I am pregnant?

There are no well-controlled studies in pregnant women; therefore, use Cardizem in pregnant women only if the potential benefit justifies the potential risk to the fetus.

 

Can I take this while breastfeeding?

Diltiazem is excreted in human milk. One report suggests that concentrations in breast milk may approximate serum levels. If use of Cardizem is deemed essential, an alternative method of infant feeding should be instituted.

 

Can I crush or split the capsule?

Do not open chew or crush, swallow whole. 

 

Can I take Cardizem with nitroglycerine?

Sublingual nitroglycerine may be taken as required to abort acute anginal attacks during Cardizem CD (diltiazem hydrochloride) therapy.

 

Can I take Cardizem with other antihypertensives?

Cardizem CD has an additive antihypertensive effect when used with other antihypertensive agents. Therefore, the dosage of Cardizem CD or the concomitant antihypertensives may need to be adjusted when adding one to the other.

Related Drugs

Reference:

Cardizem {package insert}. Bridgewater NJ: BTA Pharmaceuticals, Inc.; 2009.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020062s040lbl.pdf

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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