Caduet (Amlodipine/Atorvastatin)

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Amlodipine-Atorvastatin 5mg/40mg

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Caduet 5mg/10mg

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Caduet (Amlodipine-Atorvastatin) Medication Information

Uses

Caduet is a combination of amlodipine besylate, a calcium channel blocker, and atorvastatin calcium, a HMG CoA-reductase inhibitor, indicated in patients for whom treatment with both amlodipine and atorvastatin is appropriate. 

Amlodipine is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. Amlodipine is indicated for the treatment of Coronary Artery Disease.

Atorvastatin is indicated as an adjunct therapy to diet for prevention of cardiovascular disease and hyperlipidemia.

Dosage

There are oral tablets available in several different strengths:

  • 2.5/10 mg
  • 2.5/20 mg
  • 2.4/40 mg
  • 5/10 mg
  • 5/20 mg
  • 5/40 mg
  • 5/80 mg
  • 10/10 mg
  • 10/20 mg
  • 10/40 mg
  • 10/80 mg

Side Effects

The most common side effects of Caduet include:

  • Edema
  • Dizziness
  • Flushing
  • Palpitation 
  • Myalgia
  • Diarrhea
  • Nausea
  • Fatigue
  • Somnolence
  • Abdominal pain

Speak with your doctor or pharmacist for a full list of side effects that applies to you.

Precautions

Myopathy and rhabdomyolysis: Advise patients to promptly report to their physician unexplained and/or persistent muscle pain, tenderness, or weakness. Caduet therapy should be discontinued if myopathy is diagnosed or suspected.

Hepatic transaminitis: Monitor liver enzymes before and during treatment.

Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. However, acute hypotension is unlikely.

Angina or myocardial infarction may occur with initiation or dose increase.

Interactions

Some of the common drug interactions with Caduet:

  • Tipranavir
  • Ritonavir
  • Lopinavir
  • Other lipid-lowering medications
  • Rifampin
  • Digoxin
  • Oral contraceptive
  • Grapefruit juice

Speak with your doctor or pharmacist for more information. 

Storage

Store at controlled room temperature (59º–86ºF). 

Pharmacist Tips

  • Report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.
  • Patients should adhere to their medication along with their National Cholesterol Education Program (NCEP)-recommended diet, a regular exercise program as appropriate, and periodic testing of a fasting lipid panel to determine goal attainment.

Caduet FAQs

Can I take this with food?

Caduet can be taken with or without food.

 

Can I take this if I am pregnant?

Women of childbearing age should be advised to use an effective method of birth control to prevent pregnancy while using Caduet. Discuss future pregnancy plans with your patients, and discuss when to stop Caduet if they are trying to conceive. Patients should be advised that if they become pregnant, they should stop taking Caduet and call their healthcare professional.

 

Can I take this while breastfeeding?

Women who are breastfeeding should be advised to not use Caduet. Patients who have a lipid disorder and are breast-feeding should be advised to discuss the options with their healthcare professional.

 

Can this cause muscle pain like other statins?

There is a risk of myopathy and you should report promptly any unexplained muscle pain, tenderness, or weakness particularly if accompanied by malaise or fever or if these muscle signs or symptoms persist after discontinuing Caduet.

 

How should I take Caduet?

Take Caduet once a day, exactly as your doctor tells you. Do not change your dose or stop CADUET without talking to your doctor.

 

Can Caduet be titrated?

Dosage of Caduet must be individualized on the basis of both effectiveness and tolerance for each individual component in the treatment of hypertension/angina and hyperlipidemia. Select doses of amlodipine and atorvastatin independently. Caduet may be substituted for its individually titrated components. Patients may be given the equivalent dose of Caduet or a dose of Caduet with increased amounts of amlodipine, atorvastatin, or both for additional antianginal effects, blood pressure lowering, or lipid-lowering effect.

 

Related Drugs

Reference:

Caduet {package insert}. New York, NY: Pfizer Inc.; 2015.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021540s037lbl.pdf

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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