Caduet (Amlodipine/Atorvastatin)

(℞) Prescription Required

    Caduet (Amlodipine/Atorvastatin) Dosage and Side Effects

    CADUET is a product that contains two active ingredients: amlodipine and atorvastatin.  Your doctor has prescribed CADUET to you to control your hypertension (high blood pressure) and/or to prevent angina attacks (chest pains) and to help lower your cholesterol or other fats in the blood (such as triglycerides).

    Warnings and Precautions

    Never change the dose of CADUET unless your doctor tells you to.

    Before you use CADUET talk to your doctor or pharmacist if:

    • you have thyroid problems

    • you have had a stroke or a mini stroke called a transient ischemic attack (TIA)

    • you regularly drink three or more alcoholic drinks daily

    • you are taking any other cholesterol lowering medication such as fibrates (gemfibrozil, fenofibrate), niacin or ezetimibe

    • you are taking any other prescription, non-prescription or over-the-counter products especially those listed under the section “Interactions with This Medication:”

    • you have a family history of muscular disorders

    • you had any past problems with the muscles (pain, tenderness), after using an HMG-CoA reductase inhibitor (“statin”) such as atorvastatin (LIPITOR), fluvastatin (LESCOL), lovastatin (MEVACOR), pravastatin (PRAVACHOL), rosuvastatin (CRESTOR) or simvastatin (ZOCOR)

    • you have kidney or liver problems

    • you have diabetes (as the dosage of CADUET may need to be adjusted)

    • you have undergone surgery or other tissue injury

    • you do excessive physical exercise

    • you are 65 years old or older

    • you have taken any of the following medicines before, and you had an allergic reaction:

    • amlodipine or other derivatives

      • nifedipine (e.g. ADALAT XL)

      • felodipine (e.g. PLENDIL, RENEDIL)

    • atorvastatin (LIPITOR) or other derivatives

      • simvastatin (e.g. ZOCOR)

      • lovastatin (e.g. MEVACOR)

      • pravastatin (e.g. PRAVACHOL)

      • fluvastatin (e.g. LESCOL)

      • rosuvastatin (e.g. CRESTOR)

    • you are taking cyclosporine (e.g. SANDIMMUNE, NEORAL)

    • you are taking fusidic acid.

    Slightly increased blood sugar can occur when you take CADUET. Discuss with the doctor your risk of developing diabetes.

    CADUET may cause muscle pain, aching or weakness that does not go away even after stopping the drug.


    • Before using this medication, discuss the following with your doctor:

      • If you are breast-feeding your baby, you should not take CADUET. This medicine may be present in your breast milk.

      • Cholesterol compounds are essential elements for the development of a fetus. Cholesterol-lowering drugs can harm the fetus. If you are of child-bearing age, discuss with your doctor the potential hazards to the fetus and the importance of birth control methods.

      • This medicine should not be used by pregnant women. If you become pregnant, discontinue use immediately and discuss with your doctor.

    Side Effects

    Along with its intended action, any medication may cause unwanted effects. CADUET is generally well tolerated. However, check with your doctor or pharmacist promptly if any of the following persist or become troublesome:

    • stomach pain or upset, vomiting or throwing up, loss of appetite and inability to eat, or malaise (general feeling of being unwell), burping

    • gas, constipation, diarrhea

    • headache, neck pain

    • fever

    • hair loss

    • skin rash, hives, itchiness

    • insomnia (difficulty sleeping), drowsiness, fatigue, nightmares

    • impotence (inability of develop or maintain an erection of the penis)

    • blurred vision, ringing in the ears

    Possible side effects reported with some statins:

    • breathing problems including persistent cough and/or shortness of breath or fever

    • mood related disorders including depression

    • poor memory, confusion and memory loss

    CADUET can cause abnormal blood test results. Your doctor will decide when to perform blood tests and will interpret the results.

    Interactions with this medication

    As with most medicines, interactions with other drugs are possible. Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines. Also mention if you drink alcoholic beverages.

    Drugs that may interact with CADUET include:

    • corticosteroids (cortisone-like medicines)

    • cyclosporine (e.g. SANDIMMUNE, NEORAL), tacrolimus

    • gemfibrozil (LOPID)

    • fenofibrate (e.g. LIPIDIL MICRO)

    • bezafibrate (e.g. BEZALIP)

    • lipid-modifying doses of niacin (nicotinic acid)

    • spironolactone

    • cimetidine

    • erythromycin, clarithromycin or azole antifungal agents (ketoconazole or itraconazole)

    • nefazodone (e.g. SERZONE)

    • indinavir sulfate (e.g. CRIXIVAN), nelfinavir mesylate (e.g. VIRACEPT), ritonavir (e.g. NORVIR), saquinavir mesylate (INVIRASE), lopinavir/ritonavir (e.g. KALETRA), telaprevir (INCIVEK), tipranavir (APTIVUS), darunavir (PREZISTA), fosamprenavir (TELZIR), boceprevir (VICTRELIS)

    • fusidic acid (e.g. FUCIDIN)

    • digoxin

    • diltiazem

    • efavirenz, rifampin

    • sildenafil (VIAGRA) may lower your blood pressure

    • beta-blockers (medicines used to lower your blood pressure)

    • antacids (frequent use) and CADUET should be taken 2 hours apart

    • St. John's Wort (Hypericum perforatum)

    • grapefruit juice

    • colchicine

    Certain non-prescription drugs may be harmful to you or may interfere with CADUET.

    Proper Use of this medication

    Take CADUET exactly as prescribed by your doctor, nurse or pharmacist. Swallow CADUET with water.

    Usual Dose:

    The dose range for CADUET is 5/10 to 10/80 mg once daily. The maximum dose of CADUET is 10/80 mg once daily. CADUET is available in a broad dose-range. Your doctor will decide on the best dose for you. Your individual health and tolerance to medications will help your doctor decide how much of each ingredient will be best for you.

    Follow your doctor's dosing instructions carefully. Take your CADUET as a single dose once a day. Never change the dose unless your doctor tells you to. It does not matter if you take CADUET with food or without food. Ideally, so you won't forget, you should get in the habit of taking your medicine at the same time every day. Follow the plan that you and your doctor make for diet, exercise, weight control and smoking cessation.

    We often cannot see or feel the problems that high cholesterol and high blood pressure cause until a lot of time has passed or until a major event like a heart attack occurs. You and your doctor will be following your cholesterol and blood pressure levels to bring them down and keep them in a safe range. Here are some important tips to consider:

    • Report to all follow-up visits scheduled by your doctor. This is important to follow through with all lab tests requested by your doctor. These tests will help to follow/track your health in general, for example, your kidneys, liver and blood sugar levels.

    • It is important to take all of your medication and to refill your prescription on time so as not to miss any doses.

    • Don't drink too much alcohol while you are taking CADUET. Talk to your doctor about how much is too much for you.

    • If you get sick, have an operation, or need medical treatment, inform your doctor or pharmacist that you are taking CADUET.

    • If you have to take any other medicine—prescription, non-prescription or over-the-counter—while you are taking CADUET, talk to your doctor or pharmacist first.

    • If you have to see a different doctor for any reason, be sure to inform him/her that you are taking CADUET.

      Missed dose:

      If you miss taking your medicine, take it as soon as you can. But if it is almost time for your next dose, skip the missed dose and just take the next dose. Don't take a double dose.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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