Boniva (Ibandronate)

(℞) Prescription Required

    Boniva (Ibandronate) Dosage and Side Effects

    BONIVA is used to prevent and treat osteoporosis — a condition in which bones become weak and break easily — in women who've been through menopause.

    Proper Use of this medication

    BONIVA comes in oral and intravenous forms.

    Oral BONIVA comes as a tablet to take by mouth. It's typically taken once a day as a tablet of 2.5 milligrams (mg), or once a month as a tablet of 150 mg.

    Take the tablet first thing in the morning, at least one hour before you eat or drink anything or take any other medication.

    If you take your tablet once a month, take it on the same day each month, first thing in the morning.

    Never take your tablet at bedtime.

    Take BONIVA with a full glass of plain water. Don't take the medicine with other liquids such as tea, juice, coffee, or mineral water.

    Don't cut, crush, chew, or suck on the tablet. Swallow it whole.

    Don't lie down for at least an hour after you take a BONIVA tablet. You must sit or stand upright during this time.

    Follow the instructions on your prescription label carefully when taking BONIVA. Don't take more or less medicine than is recommended.

    BONIVA may damage your esophagus, cause mouth sores, or not work properly if you don't follow the instructions provided.

    Tell your doctor if you don't understand how to take this medicine.

    Intravenous BONIVA is typically injected into a vein once every three months. It is administered by a healthcare provider.

    BONIVA Overdose

    Symptoms of a BONIVA overdose may include:

    • Nausea
    • Stomach pain
    • Heartburn
    • Diarrhea
    • Muscle cramps
    • Tight muscles in your face
    • Seizures
    • Unusual thoughts or behaviors

    If you suspect an overdose, drink a full glass of milk and contact a poison control center or emergency room immediately.

    You can get in touch with a poison control center at 800-222-1222.

    Missed Dose of BONIVA

    If you forget to take a daily 2.5 mg tablet of BONIVA, skip your missed dose and continue on your regular medication schedule the following morning.

    If you forget to take a monthly 150 mg tablet of BONIVA, take it the morning after you remember if your next scheduled dose is more than seven days away.

    If your next scheduled dose is seven or fewer days away, skip the missed dose and wait for your next scheduled dose. Don't take two 150 mg tablets in one week.

    Side Effects

    Common Side Effects of BONIVA

    Tell your doctor if any of the following side effects become severe or don't go away:

    • Headache
    • Back pain
    • Redness or swelling of the eyes
    • Diarrhea
    • Nausea or upset stomach
    • Flu-like symptoms
    • Redness or swelling at the injection site (if you receive a BONIVA injection)
    • Pain in your arms or legs
    • Weakness
    • Dizziness
    • Frequent urination

    Serious Side Effects of BONIVA

    Tell your doctor right away if you experience any of the symptoms listed in the BONIVA Warnings section above, or any of the following serious side effects:

    • New or worsening heartburn
    • Chest pain
    • New or unusual pain in the hips or thighs
    • Difficult or painful swallowing
    • Pain or burning sensation under the ribs or in the back
    • Rash
    • Signs of anaphylaxis, a severe allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, or throat)

    Warnings and Precautions

    Before taking BONIVA, tell your doctor if you have, or have ever had:

    • Anemia(reduced hemoglobin or red blood cell amount)
    • Difficulty swallowing or problems with your esophagus
    • Heartburn
    • Ulcers or other stomach problems
    • Cancer
    • Any type of infection
    • Kidney disease
    • Low levels of calcium in your blood
    • Vitamin D deficiency
    • Problems with your mouth, teeth, or gums

    Also, let your doctor know if you're currently undergoing radiation therapy.

    Don't take BONIVA tablets if you can't sit or stand upright for at least an hour.  

    In rare instances, BONIVA can cause bone loss of the jaw (known as osteonecrosis).

    You're more likely to develop this condition if you take BONIVA for a long period of time.

    Symptoms of osteonecrosis may include:

    • Jaw pain or numbness
    • Red or swollen gums
    • Loose teeth
    • Slow healing after dental work

    A dentist should examine your teeth and perform any needed dental work before you start taking BONIVA.

    Make sure to brush your teeth and clean your mouth regularly while taking this medicine.

    Tell your doctor you take BONIVA before having any dental treatments.

    BONIVA may cause severe bone, joint, or muscle pain. This reaction can happen within days, months, or years of starting your treatment.

    Call your doctor immediately if you have severe pain at any time while taking BONIVA.

    BONIVA may also raise the risk of breaking your thigh bone. Talk to your doctor about this risk.

    Your doctor may suggest that you adopt a diet featuring foods rich in vitamin D and calcium while taking this drug. Follow your doctor's instructions.

    BONIVA helps control osteoporosis, but it doesn't cure the condition. Continue taking the medicine even if you feel well.

    Don't stop taking BONIVA without first talking to your doctor.

    Your doctor will likely order frequent tests to check your body's response to BONIVA. Keep all appointments with your doctor and laboratory.

    Pregnancy and BONIVA

    It's not known whether BONIVA can harm an unborn baby.

    Talk to your doctor if you're pregnant or might become pregnant while taking this medicine.

    It's also not known whether the drug passes into breast milk.

    Talk to your doctor if you're taking BONIVA and plan on breastfeeding.

    Interactions with this medication

    Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:

    • Angiogenesis inhibitors such as Afinitor and Zortress (everolimus), Avastin (bevacizumab), Nexavar (sorafenib), Sutent (sunitinib), or Votrient (pazopanib)
    • Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), such as Advil, Ibu-Tab, Motrin, and others (ibuprofen); or Aleve, Naprelan, Naprosyn, and others (naproxen)
    • Chemotherapy for cancer
    • Oral steroids such as Decadron (dexamethasone), Medrol (methylprednisolone), or Rayos (prednisone)

    Be sure to take any oral medicines, including vitamins and supplements, at least an hour after taking BONIVA.

    BONIVA and Alcohol

    Avoid consuming large amounts of alcohol while taking BONIVA.

    Talk to your doctor about how much alcohol is safe to drink if you're taking BONIVA or any other prescription drug.

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    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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