Actonel (Risedronate)

(℞) Prescription Required

    Actonel (Risedronate) Dosage and Side Effects

    ACTONEL is used to prevent and treat osteoporosis.

    Proper Use of this medication

    As with all medications, it is important to take as directed by your doctor.

    Missed dose:

    Daily dose (ACTONEL 5 mg or 30 mg tablet):

    If you forget to take your dose, do not double your next dose (i.e., do not take 2 tablets on the same day). Simply take 1 tablet at your next scheduled time.

    Weekly dose (35 mg ACTONEL tablet or 35 mg ACTONEL DR tablet):

    If you forget to take your dose on the regularly scheduled day, simply take 1 tablet on the day you first remember having missed your dose. Then resume your schedule by taking 1 tablet on the originally chosen day of the week. If you've missed your dose by exactly one week, do not take 2 tablets on the same day. Simply take 1 tablet as you normally would have on this day and resume your usual weekly schedule.

    Monthly duet dose (ACTONEL 75 mg tablet):

    If you miss one or both tablets of your dose of ACTONEL 75 mg in the morning, do not take it later in the day. If the next month's scheduled doses are more than 7 days away do the following:

    • If both tablets were missed, take the first ACTONEL 75 mg tablet on the morning after the day it is remembered and the second tablet on the next consecutive morning.
    • If only one tablet is missed, take the missed tablet on the morning after the day it is remembered.

    You should then continue your usual schedule of ACTONEL 75 mg on two consecutive days each month. Do not take more than two 75 mg tablets within 7 days.

    If the next month's scheduled doses are 1 to 7 days away, you should wait until next month's scheduled doses and then resume taking ACTONEL 75 mg on two consecutive days each month as originally scheduled.

    Once monthly dose (ACTONEL 150 mg tablet):

    If you miss the 150 mg dose of ACTONEL (1 tablet of 150 mg) in the morning, do not take it later in the day. If the next month's scheduled dose is more than 7 days away, take the missed tablet on the morning after the day it is remembered. You should then return to your usual schedule of ACTONEL 150 mg.

    If the next month's scheduled dose is 1 to 7 days away, you should wait until next month's scheduled dose and then resume taking ACTONEL 150 mg as originally scheduled. Do not take more than 150 mg of ACTONEL within 7 days. 

    Side Effects

    ACTONEL may cause problems in your esophagus, stomach and intestines, including ulcers. If you have trouble or pain upon swallowing, heartburn, chest pain and black or bloody stools, stop taking ACTONEL and tell your doctor right away.

    ACTONEL side effects:

    In clinical studies of osteoporosis with ACTONEL, the most commonly reported side effects were abdominal pain, heartburn and nausea. In studies of Paget's disease, diarrhea and headache were also commonly reported.  ACTONEL may cause pain in bones, joints or muscles, rarely severe. Pain may start as soon as one day or up to several months after starting ACTONEL.  ACTONEL at monthly doses may cause short-lasting, mild flu-like symptoms. These symptoms usually decrease after subsequent doses.

    Rarely patients have reported non-healing jaw wounds while receiving ACTONEL or other drugs in this class. Consult your doctor if you experience persistent pain in your mouth, teeth or jaw, or if your gums or mouth heal poorly.

    Very rarely patients have reported unusual fractures in their thigh bone while receiving drugs in this class. Consult your doctor if you experience new or unusual pain in your hip, groin, or thigh.

    ACTONEL DR side effects:

    Other side effects of ACTONEL DR include:

    Most common side effects:

    • Abdominal pain, heartburn, nausea.

    Other common side effects:

    • Pain in bones, joints, or muscles, rarely severe. The pain may start as soon as one day or up to several months after starting ACTONEL DR.
    • Diarrhea, constipation, inflammation of the pharynx and/or nose, upper respiratory tract infection.

    Rare side effects:

    • Non-healing jaw. Talk to your doctor if you experience persistent pain in your mouth, teeth or jaw, or if your gums or mouth heal poorly.

    Very rare side effects:

    • Unusual fractures in the thigh bone. Talk to your doctor if you experience new or unusual pain in your hip, groin or thigh.

    Warnings and Precautions

    Before you use ACTONEL talk to your doctor or pharmacist if:

    • You have had problems or disease in your kidneys, esophagus (the tube connecting the mouth and the stomach), stomach or intestines.
    • You cannot carry out dosing instructions.
    • You are pregnant or nursing.
    • You have one of the following risk factors: cancer, chemotherapy, radiotherapy of the head or neck, treatment with corticosteroids or dental problems or dental infections. If so, a dental examination and any necessary dental procedures should be considered before you start treatment with ACTONEL

    Calcium and vitamin D are also important for strong bones. Your doctor may ask you to take calcium and vitamin D while you are on ACTONEL therapy.

    Interactions with this medication

    It is important to tell your health care providers, including doctors and dentists, about all medications you are taking, even if the medicine does not require a prescription (including vitamin and herbal supplements).

    ACTONEL:

    You should not take ACTONEL with food, as it may prevent your body from absorbing or using ACTONEL. You should take ACTONEL on an empty stomach.

    Vitamins, mineral supplements, antacids and other medications may contain substances (e.g., calcium, magnesium, aluminum, and iron) which can stop your body from absorbing or using ACTONEL. These medications should be taken at a different time of day than ACTONEL.

    If you are taking ACTONEL for Paget's disease, talk to your doctor before taking ASA or other non-steroidal anti-inflammatory drugs used for pain management because the risk of stomach upset may be increased.

    ACTONEL DR:

    ACTONEL DR should be taken with food. Talk to your doctor to ensure that you fully understand which dosage form you have been prescribed. Medicines which reduce stomach acid [such as Proton Pump Inhibitors (PPIs) and H2 blockers] can affect the absorption of ACTONEL DR. Discuss with your doctor or pharmacist how and when to take these medications.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.