Altace (Ramipril)(℞) Prescription Required - Altace is also marketed as Cardace and Tritace
Altace (Ramipril) Dosage and Side Effects
ALTACE is used to treat high blood pressure (hypertension).
Warnings and Precautions
ALTACE carries a black-box warning because the drug may cause harm and death to a developing fetus. Do not take ALTACE if you are pregnant or plan on becoming pregnant.
People who are hypersensitive to ACE inhibitors should not use ALTACE.
Additionally, people with diabetes or kidney impairments should not take ALTACE at the same time as aliskiren (Tekturna).
The use of ACE inhibitors, including ALTACE, has been associated with the following health problems:
- An increased risk of angioedema (swelling under the skin) in people with a prior history of the condition or people taking mTOR inhibitors (a class of anti-cancer medications). Depending on where it occurs, it can cause pain, and difficulty swallowing and breathing.
- Impaired liver function and failure
- Impaired kidney function
- Neutropenia and agranulocytosis (conditions associated with low counts of neutrophils, a type of white blood cell)
Pregnancy and ALTACE
ALTACE can harm a developing fetus, particularly when taken during the second and third trimesters.
Drugs like ALTACE can reduce the kidney function of the unborn baby, as well as cause poor development of the baby's lungs and bones.
ALTACE is also associated with numerous other problems for newborns, including death. ALTACE should not be taken if you are pregnant or plan on becoming pregnant.
ALTACE is excreted in human breast milk and should not be taken if you are breastfeeding.
Common Side Effects of ALTACE
The most common side effects of ALTACE are:
Less common side effects of the drug include:
- Hypotension and dizziness that occurs after standing up from a sitting or lying position
- Chest pain
- Urinating less often and other indications of abnormal kidney function
Rare Side Effects of ALTACE
ALTACE may cause a wide range of rare health problems that may require medical attention. These include but are not limited to:
- Heart palpitations
- Jaundice (yellowing of your skin or eyes)
- Gastrointestinal issues, including abdominal pain, poor appetite (anorexia), constipation, and dry mouth
- Light sensitivity
- Stevens-Johnson syndrome (an immune condition that causes swelling and several skin problems)
- Purple skin rash (purpura)
- Anxiety and depression
- Ringing in the ears (tinnitus) and hearing loss
- Increased sweating
- Weight gain
- Labored breathing
Interactions with this medication
You should always tell your doctor about any prescription, non-prescription, illegal, and recreational drugs; herbal remedies; and nutritional and dietary supplements you're taking, especially:
- Aliskiren (Tekturna)
- Losartan (Cozaar), valsartan (Diovan), telmisartan (Micardis), and other ARBs
- Spironolactone (Aldactone), amiloride (Midamor), and certain other diuretics
- Potassium supplements
- Gold sodium thiomalate (Myochrysine)
- Non-steroidal anti-Inflammatory drugs (NSAIDs) if you are elderly, dehydrated, or have compromised kidney function.
Temsirolimus (Torisel), and other mTOR inhibitors used to treat kidney cancer.
Proper Use of this medication
ALTACE is a hard gelatin capsule that comes in three strengths: 1.25 milligrams (mg), 2.5 mg, 5 mg, and 10 mg.
The capsules should be taken whole.
If you have difficulty swallowing the capsule, you can open it and sprinkle the drug contents onto a small amount (about 4 ounces) of applesauce, or mix it into 4 ounces of water or apple juice.
If you have high blood pressure, your doctor will prescribe an initial, daily dose of 2.5 mg to 20 mg. After 2 to 4 weeks, the dosage is usually adjusted according to how your blood pressure responds to the medication.
If you are taking ALTACE to reduce your risk of a major cardiovascular events, your doctor will likely prescribe a daily dose of 2.5 mg for one week, then 5 mg once daily for three weeks, and finally 10 mg once daily if you tolerate the drug well.
If you've had a heart attack, your doctor may prescribe 2.5 mg of ALTACE twice daily to prevent heart failure. Your doctor may decrease the dose by half if the drug causes your blood pressure to drop too low.
If you are tolerating the drug, you can expect a dose increase every three weeks until you are taking 5 mg of ALTACE twice a day.
Dosages may differ for people with impaired kidney function or who are dehydrated.
Other related products
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.