Zestril (Lisinopril)

Zestril is marketed in Canada as Prinivil and generic equivalent of Zestril is Lisinopril

    Zestril (Lisinopril) Dosage and Side Effects

    ZESTRIL is a medication prescribed to treat high blood pressure. Doctors also prescribe ZESTRIL in combination with other drugs to treat congestive heart failure. ZESTRIL is in a class of medications called angiotensin-converting enzyme inhibitors, or ACE inhibitors. It works by widening blood vessels, which allows blood to flow more smoothly and lets the heart function more efficiently. By lowering blood pressure, ZESTRIL also helps reduce the risk for stroke and heart attack.

    Proper Use of this medication

    Take ZESTRIL exactly as prescribed. It is recommended to take your dose at about the same time every day.

    Swallow the tablet with a drink of water. It does not matter if you take ZESTRIL before or after food.

    Do not stop taking your tablets if you are feeling well, unless your doctor tells you.

    Usual dose:

    Adults:

    High blood pressure:

    The usual recommended starting dose is 10 mg taken once daily.

    Heart failure:

    The usual recommended starting dose is 2.5 mg taken once a day. The usual long-term dose is 5 to 35 mg taken once daily.

    Following a heart attack:

    The usual recommended starting dose is 5 mg on day 1 and day 2, then 10 mg taken once a day.

    Children (6 years of age or older):

    Children weighing 20 to less than 50 kg:

    The recommended starting dose is 2.5 mg. The maximum dose is 20 mg.

    Children weighing 50 kg or more:

    The recommended starting dose is 5 mg. The maximum dose is 40 mg.

    Overdose

    If you think you have taken too much ZESTRIL contact your doctor, nurse, pharmacist, hospital emergency department or regional Poison control Centre immediately, even if there are no symptoms.

    Missed dose:

    If you have forgotten to take your dose during the day, carry on with the next one at the usual time. Do not double dose.

    Side Effects

    Side effects may include:

    • dizziness (or light-headedness), drowsiness, fatigue, headache, tiredness, weakness (loss of strength)

    • cough, running nose

    • itching, psoriasis, sinus pain, skin rash, wheezing

    • abdominal pain, diarrhea, nausea, stomach pain and indigestion, vomiting

    • confusion, feeling sleepy or difficulty in going to sleep, mood changes (including signs of depression), seen and/or heard hallucinations, strange dreams

    • changes in the way things smell or taste, dry mouth, numbness or tingling in the fingers or toes

    • rapid heartbeat

    • impotence

    • hair loss

    • anemia

    In patients with high blood pressure, fainting is uncommon. However, fainting may become common in patients with heart failure.

    In patients with coronary heart disease, an excessive drop in blood pressure may be experienced.

    If any of these affects you severely, tell your doctor, nurse or pharmacist.

    ZESTRIL can cause abnormal blood test results. Your doctor will decide when to perform blood tests and will interpret the results.

    This is not a complete list of side effects. For any unexpected effects while taking ZESTRIL, contact your doctor, nurse, or pharmacist.

    Warnings and Precautions

    Serious Warnings and Precautions—Pregnancy

    ZESTRIL should not be used during pregnancy. If you discover that you are pregnant while taking ZESTRIL, stop the medication and contact your doctor, nurse, or pharmacist as soon as possible.

    Before you use ZESTRIL talk to your doctor, nurse or pharmacist if you:

    • Are allergic to any drug used to lower blood pressure.

    • Have recently received or are planning to get allergy shots for bee or wasp stings.

    • Have narrowing of an artery or a heart valve.

    • Have had a heart attack or stroke.

    • Have heart failure.

    • Have diabetes, liver or kidney disease.

    • Are on dialysis.

    • Are dehydrated or suffer from excessive vomiting, diarrhea, or sweating.

    • Are taking a salt substitute that contains potassium, potassium supplements, or a potassium-sparing diuretic (a specific kind of “water pill”).

    • Are on a low-salt diet.

    • Are taking a medicine that contains aliskiren, such as Rasilez, used to lower high blood pressure. The combination with ZESTRIL is not recommended.

    • Are taking an angiotensin receptor blocker (ARB). You can recognize an ARB because its medicinal ingredient ends in “-SARTAN”.

    • Are receiving gold (sodium aurothiomalate) injections.

    • Are taking drugs such as:

      • Temsirolimus and everolimus (used to treat cancer),

      • Sirolimus (used to prevent organ rejection after a transplant).

      Taking ACE inhibitors, such as ZESTRIL with these types of drugs may increase your chances of having an allergic reaction (angioedema).

    Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e.g. potassium) in your blood at regular intervals.

    You may become sensitive to the sun while taking ZESTRIL. Exposure to sunlight should be minimized until you know how you respond.

    If you are going to have surgery and will be given an anesthetic, be sure to tell your doctor or dentist that you are taking ZESTRIL.

    Driving and using machines:

    Before you perform tasks which may require special attention, wait until you know how you respond to ZESTRIL. Dizziness, lightheadedness, or fainting can especially occur after the first dose and when the dose is increased.

    Interactions with this medication

    As with most medicines, interactions with other drugs are possible. Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines.

    The following may interact with ZESTRIL:

    • Agents increasing serum potassium, such as a salt substitute that contains potassium, potassium supplements, or a potassium-sparing diuretic (a specific kind of “water pill”).

    • Allopurinol used to treat gout.

    • Drugs to treat diabetes such as:

      • Insulin,

      • Oral medications (such as sulphonylureas).

      Your dose of these types of drugs may need to be changed when taking them in combination with ZESTRIL.

    • Temsirolimus and everolimus (drugs to treat cancer).

    • Gold for the treatment of rheumatoid arthritis.

    • Lithium used to treat bipolar disease.

    • Non-steroidal anti-inflammatory medicines (NSAIDs), used to reduce pain and swelling. Examples include ibuprofen, naproxen, and celecoxib.

    • Blood pressure-lowering drugs, including diuretics (“water pills”), aliskiren-containing products (e.g. Rasilez), or angiotensin receptor blockers (ARBs).

    • Sirolimus, a drug used to prevent the organ rejection after a transplant.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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