Aldactone (Spironolactone)

(℞) Prescription Required

    Aldactone (Spironolactone) Dosage and Side Effects

    ALDACTONE is used to treat high blood pressure and fluid retention (edema) caused by various conditions, including heart disease, cirrhosis of the liver and nephrotic syndrome. It is also used to treat hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); and low potassium levels in the blood (hypokalemia).

    Proper Use of this medication

    ALDACTONE comes as a tablet to take by mouth. Take it exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. It usually is taken once a day in the morning with breakfast or twice a day with breakfast and lunch. Carefully follow your doctor's instructions about any special diet.

    Missed dose:

    Take the missed dose as soon as you remember it. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take a double dose to make up for a missed one.

    Side Effects


    constipation, diarrhea, nausea, vomiting, decreased appetite, upset stomach, enlargement of the glands in your mouth, indigestion, dryness of mouth, abdominal pain, and cramps.

    Central nervous system:

    dizziness, pins and needles in your fingers, headache, a feeling that you or your surroundings are moving, sensation of tingling or numbness and drowsiness.


    low blood pressure while you are standing (postural hypotension), may be aggravated by alcohol, barbiturates, or narcotics.


    fever, difficulty breathing anaphylactic reactions.


    muscle cramps, spasms, and pain, weakness, restlessness.


    reduced libido.


    In men: breast swelling, difficulty in getting or maintaining erections. In women: breast discomfort, irregular or missed menstrual periods, postmenopausal bleeding.


    bleeding under the skin, rash, red patches on the skin.


    thirst, frequent urination, and fatigue.

    If any of these affect you severely, tell your doctor, nurse or pharmacist.

    ALDACTONE can cause abnormal blood test results. Your doctor will decide when to perform blood tests and will interpret the results.

    Warnings and Precautions

    Before you receive ALDACTONE, talk to your doctor, nurse, or pharmacist if you:

    • Have diabetes, kidney disease or liver disease;

    • Have or have ever had gout;

    • Are taking a nonsteroidal anti-inflammatory drugs (NSAIDs) used to reduce pain and swelling. Examples include Aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and celecoxib (Celebrex);

    • Are taking an angiotensin converting enzyme (ACE) inhibitor. You can recognize ACE inhibitors because their medicinal ingredient ends in “PRIL”. It lowers blood pressure;

    • Are taking an angiotensin receptor blocker (ARB). You can recognize an ARB because its medicinal ingredient ends in “-SARTAN”. It lowers blood pressure;

    • Are taking lithium used to treat bipolar disorder (manic-depressive illness);

    • Are pregnant, plan to become pregnant, or are breast feeding. If you become pregnant while taking ALDACTONE, call your doctor immediately;

    • Are a man and develop tender or enlarged breast tissue;

    • Are having surgery, including dental surgery, and will be given an anesthetic. Be sure to tell the doctor or dentist that you are taking ALDACTONE.

    Driving and using machines: Before you perform tasks which may require special attention, wait until you know how you respond to ALDACTONE. Dizziness, lightheadedness, or fainting can especially occur after the first dose and when the dose is decreased (sometimes leading to falls and fractures or broken bones). Do not drive a car or operate machinery until you know how this drug affects you. Remember that alcohol can add to the drowsiness caused by this drug.

    Interactions with this medication

    As with most medicines, interactions with other drugs are possible. Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, nonprescription drugs, vitamins, minerals, natural supplements, or alternative medicines.

    The following may interact with ALDACTONE

    • Alcohol, barbiturates (sleeping pills), or narcotics (strong pain medications). They may cause low blood pressure and dizziness when you go from lying or sitting to standing up.

    • Corticosteroids used to treat joint pain and swelling.

    • Digoxin, a heart medication

    • Drugs that cause hyperkalemia (high levels of potassium in blood)

    • Lithium used to treat bipolar disorder (manic-depressive illness)

    • Nonsteroidal anti-inflammatory drugs (NSAIDs), use to reduce pain and swelling. Examples include Aspirin, ibuprofen, naproxen, and celecoxib.

    • Other blood pressure lowering drugs, including diuretics. When taken in combination with ALDACTONE, they may cause excessively low blood pressure.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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