Aciphex (Rabeprazole)

(℞) Prescription Required - Aciphex is also marketed as Pariet

    Aciphex (Rabeprazole) Dosage and Side Effects

    ACIPHEX is used for the treatment of gastroesophageal reflux disease (GERD), a chronic digestive disorder.

    Proper Use of this medication

    ACIPHEX Overdose:

    There are no reports of large ACIPHEX overdoses, and a moderate overdose causes no symptoms.

    However, research in rodents shows that large doses of ACIPHEX cause decreased activity, difficulty breathing, and convulsions.

    In dog studies, large doses caused watery diarrhea, tremors, convulsions, and coma.

    Contact a poison control center or emergency room if you suspect you've taken too much ACIPHEX.

    Missed Dose of ACIPHEX:

    Take your missed dose as soon as possible.

    If it's almost time for your next dose, skip the missed dose and continue on your regular dosing schedule.

    Don't double up on doses to make up for a missed one.

    Side Effects

    The most common side effects of ACIPHEX in adults are:

    • Pain
    • Sore throat
    • Gas
    • Constipation
    • Infection

    In young children and adolescents, the most common side effects of ACIPHEX are:

    • Diarrhea
    • Pain
    • Headache

    Less commonly, adolescents may experience nausea and vomiting.

    Allergic reactions to ACIPHEX may result in severe side effects, including:

    • Rash
    • Face swelling
    • Throat tightening
    • Difficulty breathing

    Rare side effects in adults include:

    • Headache
    • Abdominal pain
    • Diarrhea
    • Dry mouth
    • Dizziness
    • Swollen arms and legs
    • Decreased liver function, resulting in worsening brain function
    • Hepatitis (liver inflammation)
    • Muscle or joint pain

    Interactions with this medication

    Before taking ACIPHEX, tell your doctor about all of the drugs you take, including any prescription, non-prescription, illegal, and recreational drugs; herbal remedies; and nutritional and dietary supplements you're taking, especially:

    • Digoxin (Lanoxin)
    • Cyclosporine (Restasis)
    • Atazanavir (Reyataz)
    • Ketoconazole (Nizoral)
    • Warfarin (Coumadin)
    • Theophylline (Theo-24)
    • Diazepam (Valium)
    • Phenytoin (Dilantin)
    • Antibiotics that contain amoxicillin or clarithromycin
    • Methotrexate (Trexall)
    • Diuretics

    Warnings and Precautions

    You shouldn't take ACIPHEX if you're hypersensitive to rabeprazole or other substituted benzimidazoles.

    As with other PPIs, Aciphex may increase your risk of a C. difficile infection, which causes severe diarrhea.

    Call your doctor immediately if you have watery stool, stomach pain, or persistent fever or all three infection symptoms.

    ACIPHEX may increase your risk of hip, wrist, or spine fracture if you're taking multiple doses a day.

    Additionally, prolonged use may cause a low magnesium level, which can lead to various symptoms. Inform your doctor if you experience:

    • Seizures
    • Dizziness
    • Abnormal heart rate
    • Jitteriness or tremors (uncontrollable shaking)
    • Muscle weakness
    • Spasms in the hands, feet, or voice box (larynx)
    • Cramps or muscle aches

    Pregnancy and ACIPHEX

    There's no evidence from animal studies that ACIPHEX harms developing fetuses, but research in pregnant women is inconclusive.

    You should tell your doctor if you are pregnant or might become pregnant before taking this medicine.

    ACIPHEX is excreted in rat milk, but it's not known if the same is true for human breast milk.

    You shouldn't use this drug while breastfeeding a baby without first talking to your doctor.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.