Sinequan (Doxepin) Dosage and Side Effects
SINEQUAN a prescription medication used to treat anxiety and depression. It's also used to treat insomnia (trouble with sleeping).
Proper Use of this medication
It's usually taken one to three times a day and may be taken with or without food.
Try to take SINEQUAN at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take SINEQUAN exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
It may take several weeks or longer for you to feel the full effect of SINEQUAN. Continue to take SINEQUAN even if you feel well.
Do not stop taking SINEQUAN without talking to your doctor. Your doctor will probably want to decrease your dose gradually.
Call 911 or a poison control line.
An overdose of SINEQUAN can be fatal.
Missed Dose of SINEQUAN
Take the missed dose as soon as you remember.
Skip the missed dose if it's almost time for your next scheduled dose.
Do not take extra medicine to make up the missed dose.
SINEQUAN may cause side effects. Call your doctor if any of these symptoms are severe or do not go away:
- Weakness or tiredness
- Dry mouth
- Skin more sensitive to sunlight than usual
- Changes in appetite or weight
- Difficulty urinating
- Frequent urination
- Blurred vision
- Changes in sex drive or ability
- Excessive sweating
If you experience any of the following symptoms, call your doctor immediately:
- Jaw, neck, and back muscle spasms
- Slow or difficult speech
- Shuffling walk
- Uncontrollable shaking of a part of the body
- Difficulty breathing or swallowing
- Yellowing of the skin or eyes
- Irregular heartbeat
Warnings and Precautions
You should not take SINEQUAN if you have glaucoma or problems with urination.
SINEQUAN is safe for elderly people, but there may be an increased risk of confusion or drowsiness. Dosing may also differ due to decreased kidney function or heart problems.
SINEQUAN is not approved for use in children under age 12.
Do not use if you are allergic to SINEQUAN or to similar medications such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).
Do not use SINEQUAN if you have taken a monoamine oxidase inhibitor (MAOI) in the past 14 days. A dangerous drug interaction could occur.
- Furazolidone (Furoxone)
- Isocarboxazid (Marplan)
- Linezolid (Zyvox)
- Phenelzine (Nardil)
- Rasagiline (Azilect)
- Selegiline (Emsam)
- Tranylcypromine (Parnate)
Report any new or worsening symptoms to your doctor, including:
- Behavior or mood changes, such as feeling impulsive, irritable, agitated, hostile, aggressive, or restless
- Panic attacks
- Trouble sleeping
- Increased depression
- Suicidal thoughts or thoughts of harming yourself
- Hyperactivity (mental or physical)
To make sure SINEQUAN is safe for you, tell your doctor if you have:
- Sleep apnea (breathing stops during sleep)
- Diabetes (SINEQUAN may raise or lower blood sugar)
- Bipolar disorder (manic-depression)
Some children, teenagers, and young adults have thoughts of suicide when first taking an antidepressant.
Your doctor will need to check your progress at regular visits while you are using SINEQUAN.
Your family or other caregivers should also be alert to changes in your mood or symptoms.
SINEQUAN and Pregnancy
It's not known whether SINEQUAN will harm an unborn baby.
Tell your doctor if you are pregnant or might become pregnant while using this medication.
SINEQUAN is excreted into human breast milk in small amounts. Respiratory depression has been reported in one breastfeeding infant.
Do not give this medicine to a child without medical advice.
Interactions with this medication
Taking SINEQUAN with other drugs that make you sleepy or slow your breathing can increase these effects.
Ask your doctor before taking SINEQUAN with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Before taking SINEQUAN, tell your doctor if you have used a selective serotonin-reuptake inhibitor or SSRI antidepressant in the past five weeks, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).
You must wait at least five weeks after stopping fluoxetine (Prozac) before you can take SINEQUAN.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with SINEQUAN, especially:
- Bupropion (Wellbutrin)
- Cimetidine (Tagamet)
- St. John's wort (Hypericum perforatum)
- Terbinafine (Lamisil)
- Tolazamide (Tolinase)
- Antidepressants or other medication used to treat mental illness
- Heart rhythm medications such as flecainide (Tambocor), propafenone (Rythmol), or quinidine (Quinora)
This list is not complete and many other drugs can interact with SINEQUAN.
This includes prescription and over-the-counter (OTC) medicines, vitamins, herbal supplements, and recreational drugs.
Give a list of all your medicines to any healthcare provider who treats you.
SINEQUAN and Alcohol
Do not drink alcohol while taking SINEQUAN.
SINEQUAN can increase the effects of alcohol, which could be dangerous.
SINEQUAN may impair your thinking or reaction time, so avoid driving or operating heavy machinery until you're aware of its effects on you.
Other related products
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.