Prinivil (Lisinopril)

(℞) Prescription Required - Prinivil is also marketed as Zestril

    Prinivil (Lisinopril) Dosage and Side Effects

    PRINIVIL is used to treat high blood pressure, treat heart failure, and reduce the risk of having another heart attack. It can be used alone or along with other medications to treat your condition.

    Warnings and Precautions

    Serious Warnings and Precautions

    You should not take PRINIVIL while you are pregnant. Taking it while you are pregnant can cause injury and even death to your baby. If you become pregnant while taking this drug, stop taking it and get in touch with your doctor as soon as possible.


    • you are allergic to lisinopril or to any of the other ingredients in PRINIVIL.
    • you have had an allergic reaction (angioedema):
      • to any other ACE inhibitor. You can tell you are taking or have taken an ACE inhibitor because these types of drugs have ingredients that end with “-PRIL” (such as enalapril and captopril) or
      • have been diagnosed with hereditary angioedema. This is an increased risk of getting an allergic reaction that is passed down through your family, or
      • where the reason for it is not known
    • Signs of an allergic reaction include:
      • swelling of the hands, feet, ankles, face, lips, tongue and throat
      • suddenly having trouble breathing or swallowing
    • Make sure that you tell your doctor, nurse or pharmacist that this has happened to you before.
    • have diabetes or kidney disease and are already taking:
      • a blood pressure-lowering medicine that contains aliskiren (such as Rasilez) or
      • an angiotensin receptor blocker (drugs that have ingredients that end in “-SARTAN”).
    • Taking these drugs at the same time as PRINIVIL is not recommended.

    Low Blood Pressure:

    You may feel dizzy or light headed:

    • particularly in the first few days after you start taking PRINIVIL. You should lie down if this happens. You should avoid driving or doing any tasks that require special attention.
    • when you exercise or when the weather is hot.

    If you faint, stop taking the drug and talk to your doctor.

    Blood tests:

    While you are taking PRINIVIL your doctor may do blood tests to check:

    • the level of white blood cells in your blood.
    • the potassium levels in your blood.
    • that your kidneys are working properly.


    You may develop a cough while taking PRINIVIL. This usually goes away once you stop taking it or when the dose is lowered.

    Black patients:

    you are at a higher risk for having an allergic reaction (angioedema).

    Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

    Side Effects

    These are not all the possible side effects you may feel when taking PRINIVIL. If you experience any side effects not listed here, contact your healthcare professional.

    • Dry cough
    • Sore throat
    • Stuffy or runny nose
    • Unusual tiredness and/or weakness
    • Headache
    • Pain in the abdomen
    • Hair loss
    • Changes in your mood or confusion
    • Changes in taste
    • Impotence (not able to have an erection)

    Interactions with this medication


    • Drugs that lower your blood pressure. These include:
      • diuretics (“water pills”)
      • aliskiren-containing drugs (such as Rasilez)
      • angiotensin receptor blockers (ARBs)
      • other drugs that are used to lower blood pressure
    • Drugs that can increase the levels of potassium in your blood. These include:
      • potassium-sparing drugs (such as spironolactone, triamterene or amiloride)
      • potassium supplements
      • salt substitutes that contain potassium
    • Drugs used to treat diabetes (including oral drugs and insulin)
    • Lithium (used to treat a certain kind of depression)
    • Injectable gold (in the form of gold sodium aurothiomalate) used to treat arthritis
    • Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) used to reduce pain and swelling (such as naproxen, ibuprofen and celecoxib)
    • Drugs used for mTOR inhibitor therapy (such as temsirolimus, sirolimus, everolimus). These drugs are used to lower the body’s ability to reject a transplant or to treat certain cancers. Taking these drugs together with PRINIVIL could increase the risk for an allergic reaction called angioedema.
    • Indomethacin (used to treat pain and swelling)
    • Certain drugs that you can buy without a prescription are known to cause your blood pressure to go up. These include drugs:
      • to control your hunger
      • for asthma
      • to treat colds and coughs
      • to treat allergies (such as hayfever)
      • to treat sinus problems

    You should not take these types of medicines unless you have talked it over with your doctor first.

    Proper Use of this medication

    Swallow the tablet whole. You should not split or break the tablets.

    If your doctor has given you specific instructions to follow, for example to eat a low salt diet or to lose weight, you should follow them.

    Take PRINIVIL:

    • exactly as your doctor has told you how to take it
    • once a day at about the same time every day
    • with or without food

    Usual dose:

    Your doctor has decided on the best dose for you based on your needs.

    Even if you feel better, you should not stop taking this medicine unless your doctor tells you to.


    If you think you have taken too much PRINIVIL, contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

    Symptoms of an overdose include:

    • feeling light headed or dizzy. This can happen because of a sudden or extreme drop in blood pressure.

    Missed dose:

    • If it has been less than 6 hours since you missed taking it, take your dose as soon as possible and then go back to your regular schedule.
    • If it has been more than 6 hours since you missed taking it, skip the missed dose. Take the next dose at your usual time.

    Do not take two doses at the same time.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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