Monoket (Isosorbide 5 Mononitrate)

(℞) Prescription Required

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Isosorbide Mononitrate 10mg

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Isosorbide Mononitrate 10mg
Product of United Kingdom
Manufactured by UK Various Generics
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Isosorbide Mononitrate 20mg

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Isosorbide Mononitrate 20mg
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Ismo 10mg

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Manufactured by: Roche Products Limited
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Ismo 10mg
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Ismo 20mg

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Ismo 20mg
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Monoket (Isosorbide 5 Mononitrate) Dosage and Side Effects

ISMO dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.  ISMO is used to prevent angina attacks (chest pain).

Proper Use of this medication

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Not all brands and forms of ISMO are taken the same number of times per day. You may need to take the medicine only once daily, in the morning after getting out of bed. Or you may need a second dose later in the day. Follow your doctor's dosing instructions very carefully.

If possible, try to rest or stay seated when you use this medicine. ISMO can cause dizziness or fainting.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use ISMO.

Use ISMO regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely.

You should not stop using ISMO suddenly if you take this medicine to prevent angina. Stopping suddenly may cause you to have a severe attack of angina.

Do not change brands of ISMO without the approval of your doctor.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Seek emergency medical attention or call the Poison Help line. An overdose of ISMO can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • worsening angina pain;
  • fast or slow heart rate; or
  • pounding heartbeats or fluttering in your chest.

ISMO can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use ISMO. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication.

Common side effects may include:

  • headache; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Warnings and Precautions

Do not use ISMO if you are taking medicine to treat erectile dysfunction or pulmonary arterial hypertension (PAH). This includes sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis, Adcirca), vardenafil (Levitra, Staxyn), and riociguat (Adempas). Serious, life-threatening side effects may occur.

You should not use ISMO if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling).

Do not use ISMO if you are taking medicine to treat erectile dysfunction or pulmonary arterial hypertension (PAH). This includes sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis, Adcirca), vardenafil (Levitra, Staxyn), and riociguat (Adempas). Serious, life-threatening side effects may occur.

You should not use ISMO if:

  • you are allergic to ISMO, isosorbide dinitrate, or nitroglycerin; or
  • you have early signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating).

To make sure ISMO is safe for you, tell your doctor if you have:

  • congestive heart failure;
  • low blood pressure; or
  • kidney disease (or if you are on dialysis);
  • if you take a diuretic or "water pill"; or
  • if you are on a low salt diet.

FDA pregnancy category C. It is not known whether ISMO will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether ISMO passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Interactions with this medication

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of ISMO.

Other drugs may interact with ISMO, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Other related products

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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