Lexiva (Fosamprenavir) Dosage and Side Effects
LEXIVA is an antiviral medicine that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.
Proper Use of this medication
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking LEXIVA and call your doctor at once if you have:
- chest pain or pressure, tight feeling in your neck or jaw, pain spreading to your arm or shoulder;
- pale or yellowed skin, dark colored urine, fever, confusion or weakness;
- increased urination or extreme thirst;
- sudden and severe pain in your lower back or side, blood in your urine, pain or burning when you urinate; or
- severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
LEXIVA may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with LEXIVA. Tell your doctor if you have:
- signs of a new infection--fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;
- chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;
- cold sores, sores on your genital or anal area;
- rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;
- trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or
- swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.
Common side effects of LEXIVA may include:
- fever or other signs of infection;
- nausea, vomiting, diarrhea;
- headache; or
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Warnings and Precautions
Some medicines can cause unwanted or dangerous effects when used with LEXIVA. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
You should not use LEXIVA if you are allergic to it.
There are certain medicines that can cause life-threatening drug interactions with LEXIVA, and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:
- St. John's wort;
- sildenafil (Revatio) when used to treat pulmonary arterial hypertension (PAH);
- cholesterol-lowering medicine--lovastatin, simvastatin;
- ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine;
- heart rhythm medicine--flecainide, propafenone; or
- a sedative--oral midazolam or triazolam.
To make sure LEXIVA is safe for you, tell your doctor if you have:
- liver disease;
- kidney disease;
- a bleeding disorder such as hemophilia;
- heart disease, history of heart attack;
- an allergy to sulfa drugs;
- high cholesterol or triglycerides; or
- if you have ever used a protease inhibitor in the past.
It is not known whether LEXIVA will harm an unborn baby. However, HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. Tell your doctor if you become pregnant.
Your name may need to be listed on an antiviral pregnancy registry when you start using this medicine.
LEXIVA can make birth control pills less effective. Taking LEXIVA together with ritonavir and also using birth control pills can increase your risk of abnormal liver function tests. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.
Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
LEXIVA should not be given to an infant younger than 4 weeks (28 days) old.
Interactions with this medication
Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Many drugs can interact with LEXIVA, and some drugs should not be used together. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
- other drugs to treat HIV or AIDS;
- an antibiotic or antifungal medicine;
- an antidepressant or anti-psychotic medicine;
- antiviral medicine to treat hepatitis C;
- a blood thinner (warfarin, Coumadin, Jantoven);
- cholesterol-lowering medicine;
- heart or blood pressure medicine;
- medicine to prevent organ transplant rejection;
- medicine to prevent or treat nausea and vomiting;
- medicine to treat a breathing disorder;
- narcotic medicine;
- a sedative;
- seizure medicine;
- steroid medicine;
- stomach acid reducers; or
- Viagra and other erectile dysfunction medicines.
This list is not complete and many other drugs can interact with LEXIVA. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Other related products
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.