Iopidine (Apraclonidine)

Do not use IOPIDINE ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before using IOPIDINE ophthalmic, tell your doctor if you have kidney or liver disease, heart disease, high blood pressure, or a history of fainting or low blood pressure. Also tell your doctor if you are using any medications to treat high blood pressure or a heart rhythm disorder.

You should not use this medication if you are allergic to IOPIDINE or to clonidine (Catapres).

Do not use IOPIDINE ophthalmic if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before using IOPIDINE ophthalmic, tell your doctor if you have:

• kidney disease;
• liver disease;
• heart disease or high blood pressure;
• a history of fainting or low blood pressure.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use IOPIDINE ophthalmic.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether IOPIDINE ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• slow or uneven heart rate;
• pounding heartbeats or fluttering in your chest;
• shallow breathing, feeling like you might pass out;
• severe swelling, redness, or discomfort in or around your eye;
• eye pain or increased watering; or
• numbness or tingly feeling in your hands or feet.

Less serious side effects may include:

• burning, itching, or dryness of your eyes;
• feeling like something is in your eye;
• blurred or dimmed vision;
• redness of the eye or eyelid;
• mildly swollen or puffy eyes;
• nausea, stomach pain, diarrhea;
• headache, sleep problems (insomnia);
• dry or stuffy nose, burning in your nose;
• a dry mouth; or
• unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Avoid using other medications in your eyes during treatment with IOPIDINE unless your doctor has told you to.

Before using IOPIDINE ophthalmic, tell your doctor if you are using any of the following medications:

• blood pressure medications; or
• heart rhythm medication.

This list is not complete and there may be other drugs that can interact with IOPIDINE ophthalmic. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

This medication is usually given one hour before eye surgery and again right after surgery. Your doctor, nurse, or other healthcare professional will most likely give you this medication.

If you use IOPIDINE ophthalmic at home, use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Wash your hands before using the eye drops.

Do not use this medication while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using IOPIDINE before putting your contact lenses in.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
• Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.
• Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Keep the eye drop pouches in their foil overwrap until you are ready to us the medication. Store at room temperature away from heat and moisture. Use each single-dose applicator only one time.

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of IOPIDINE ophthalmic used in the eyes is not likely to produce life-threatening side effects, but overdose symptoms may include drowsiness, slow heart rate, and decreased body temperature.

Since IOPIDINE ophthalmic is usually given as needed by a healthcare professional, it is not likely that you will miss a dose.

If you are on a dosing schedule and you forget to use your medication, apply the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.