Invokamet (Canagliflozin/Metformin)

(℞) Prescription Required

    Invokamet (Canagliflozin/Metformin) Dosage and Side Effects

    INVOKAMET is used along with diet and exercise to improve blood sugar levels in adults with type 2 diabetes.

    Proper Use of this medication

    • Take the dose prescribed for you by your healthcare professional. Your healthcare professional will prescribe the strength that is right for you.
    • Take INVOKAMET twice a day with meals to lower your chance of having an upset stomach. Swallow the tablet whole.
    • Your healthcare professional may prescribe INVOKAMET together with another medicine to help control your blood sugar.
    • Always take INVOKAMET and all other medicines prescribed to you exactly as your healthcare professional has told you. Check with your doctor or pharmacist if you are not sure.


    If you think you have taken too much INVOKAMET, contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

    Missed Dose:

    • If you forget to take a dose of INVOKAMET, take it as soon as you remember.
    • However, if it is nearly time for the next dose, skip the missed dose.
    • Do not take a double dose to make up for a forgotten dose.

    Side Effects

    These are not all the possible side effects you may feel when taking INVOKAMET. If you experience any side effects not listed here, contact your healthcare professional.

    Side effects may include:

    • Changes in urination:
      • urinating more often or in larger amounts
      • an urgent need to urinate
      • a need to urinate at night
    • Constipation, excess gas, abdominal discomfort
    • Nausea, vomiting, diarrhea, indigestion, loss of appetite
    • Changes in taste or a metallic taste
    • Feeling thirsty
    • Rash, hives
    • Headache
    • Fatigue

    Diabetic Ketoacidosis (DKA) is a serious medical condition with normal or high blood glucose levels. Get medical help right away if you have any of the symptoms in the table below under DKA, even if your blood glucose levels are normal.

    Tell your doctor if you are hospitalized for major surgery, serious infection or serious medical illness.

    Increased need for lower leg or toe amputation (removal) especially if you are at high risk of heart disease. Talk to your doctor if you experience symptoms including leg pain, poor circulation, bluish, cold skin, and poor hair and toe nail growth. Good foot care is recommended.

    If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

    Warnings and Precautions

    Stop taking INVOKAMET and tell your healthcare professional if you get the following symptoms of lactic acidosis:

    • You feel very weak and tired.
    • You have unusual (not normal) muscle pain.
    • You have trouble breathing or fast breathing.
    • You have stomach pain with nausea and vomiting, or diarrhea.
    • You feel cold, especially in your arms and legs.
    • You feel dizzy or lightheaded.
    • You feel unusual fatigue and drowsiness.
    • You have a slow or irregular heartbeat.
    • Your medical condition suddenly changes.
    • You develop or experience a worsening of heart problems and particularly heart failure.

    INVOKAMET is not recommended for use in patients under 18 years of age.

    INVOKAMET will cause your urine to test positive for sugar (glucose).

    Taking INVOKAMET increases your risk of breaking a bone. Talk to your doctor about factors that may increase your risk of bone fracture.

    While taking INVOKAMET your healthcare professional may order blood tests to check your kidney function, blood fat levels (Low-Density Lipoprotein cholesterol or LDL-C), the amount of red blood cells in your blood (haematocrit), and potassium blood levels.

    INVOKAMET may cause dizziness or light-headedness. DO NOT drive or use machines until you know how the medicine affects you.

    Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

    Interactions with this medication

    The following may interact with INVOKAMET:

    • digoxin, used to treat heart problems.
    • furosemide or other diuretics (water pills), used to treat high blood pressure and other heart problems.
    • insulin or a sulfonylurea (such as glimepiride, gliclazide, or glyburide), used to help control blood sugar.
    • carbamazepine, phenytoin or phenobarbital, used to treat seizures.
    • barbituates, used as sedatives and sleep-aids.
    • efavirenz or ritonavir, used to treat HIV infection.
    • rifampin, an antibiotic used to treat bacterial infections such as Tuberculosis.
    • St. John’s wort, an herbal product used to treat depression.
    • nifedipine, a calcium channel blocker used to treat heart problems.
    • Angiotensin-Converting Enzyme (ACE) inhibitors, Angiotensin Receptor Blockers (ARB) used to treat high blood pressure.
    • phenprocoumon and other drugs used prevent blood clots and thin the blood.
    • birth control pills and other products containing estrogens.
    • alcohol.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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