Cytoxan (Cyclophosphamide) Dosage and Side Effects
CYTOXAN, a chemotherapy drug for people with certain cancers. It’s prescribed for non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma, small-cell lung cancer (SCLC), leukemia, ovarian cancer, retinoblastoma, neuroblastoma, and breast cancer. CYTOXAN is sometimes used to treat kidney damage.
Warnings and Precautions
You shouldn’t take CYTOXAN if any of the following situations apply to you:
•You are allergic to CYTOXAN or any other component in the drug.
•You have had radiation treatment in the past.
•Your absolute neutrophil count (ANC) is less than 1,500.
•Your platelet count (PLT) is less than 50,000.
Talk to your doctor before taking CYTOXAN if you are 65 years old or older and have:
•Kidney or liver disease
•An open wound that’s currently healing
•Have previously taken a drug that can damage your heart or are taking one now
Pregnancy and CYTOXAN
CYTOXAN can affect a developing fetus.
You and your doctor need to decide whether the benefits of taking the drug during pregnancy outweigh the risk.
CYTOXAN is found in breast milk and isn’t considered safe to use while breastfeeding.
Tell your doctor if you’re pregnant, planning a pregnancy, or are breastfeeding before you take CYTOXAN.
Common Side Effects of CYTOXAN
•Nausea and vomiting
•Hair loss and baldness
•Skin darkening, a rash, and changes in nails
•Missed periods and inability to conceive
•Low platelet and white blood cell counts
Serious Side Effects of CYTOXAN
•Decrease in red and white blood cells and platelets
•Weakened immune system and serious infections
•Bladder infection and stiffening of bladder tissue (urinary fibrosis)
•Irregular heart beat
•Congestive heart failure
•Severe and potentially life-threatening skin reaction
Interactions with this medication
Tell your doctor and pharmacist about all the medications you’re taking.
This includes prescriptions and over-the-counter medications, vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbal remedies, and illegal and recreational drugs.
You shouldn’t take CYTOXAN if you are taking the following drugs:
•Adenovirus vaccine live
•BCG live intravesical (Theracrys)
•Live influenza nasal vaccine (FluMist and FluMist Quadrivalent)
•Live measles/mumps/rubella vaccine (MMR) (M-M-R II)
•Live rotavirus vaccine (Rotarix, Rotateq)
•Smallpox vaccine (Dryvax )
•Live typhoid vaccine (Vivotif)
•Live varicella vaccine (Varivax)
•Live yellow fever vaccine (YF- Vax)
•Live zoster vaccine (Zostavax)
Talk to your doctor about the potential for serious interactions before your are given CYTOXAN if you are taking any of the following drugs:
•Carbamazepine (Carbatrol, Equetro,Tegretol)
•Idarubicin (Idamycin PFS)
CYTOXAN and Alcohol
Avoid or limit drinking while taking CYTOXAN.
CYTOXAN and Grapefruit Juice
Grapefruit interferes with how quickly the liver processes cyclophosamide and increases the risk and severity of the many dangerous side effects of CYTOXAN.
Avoid consuming grapefruit and the juice while taking CYTOXAN.
Proper Use of this medication
Only an appropriately trained health care professional can administer CYTOXAN, since it's injected into your veins.
Your doctor will determine how much CYTOXAN you should receive based on your weight and the condition for which you are being treated.
Other related products
The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.