Contrave (Naltrexone/Bupropion)

(℞) Prescription Required

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Contrave 8mg/90mg

Product of United Kingdom
Manufactured by: Orexigen Therapeutics Ireland Ltd.
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Contrave 8mg/90mg
Product of United Kingdom
Manufactured by Orexigen Therapeutics Ireland Ltd.
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Contrave 8mg/90mg

Product of Canada
Manufactured by: Bausch Health Canada
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Contrave 8mg/90mg
Product of Canada
Manufactured by Bausch Health Canada
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Contrave Coupon

Contrave Coupon

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Contrave (Naloxone-Bupropion) Medication Information


Contrave is a medicine that contains an opioid antagonist and an aminoketone antidepressant that is used for weight loss. 


The tablets are available in 8/90 mg strength.

Side Effects

The most common side effects of Contrave include:

  • Headache
  • Nausea
  • Constipation
  • Diarrhea
  • Vomiting
  • Dizziness
  • Insomnia 

Speak with your doctor for a full list of side effects that apply to you if you are taking Contrave.


Contrave can increase a patient’s suicide ideation and behavior, so patients should be monitored for this effect. 

There is an increased risk of seizures while using Contrave. 

There is a possible risk of liver dysfunction while taking Contrave. 

If patients are using antidiabetic medication, they can also experience hypoglycemia with the addition of Contrave. 


A common drug interaction with Contrave includes:

  • MAOIs
  • SSRI
  • SNRIs
  • Clopidogrel
  • Carbamazepine
  • Phenobarbital
  • Phenytoin
  • Levodopa
  • Amantadine 

Speak with your doctor for more information and before starting a new medication with Contrave. 


Store at 77 ºF. 

Pharmacist Tips

  • Contrave needs to be taken exactly as it is prescribed.
  • Contrave contains an antidepressant that can be found in other medications and it should not be used with them.
  • . There is a risk of suicide while taking Contrave.

Contrave FAQs

How much weight can you lose on Contrave?

On average patients in the clinical trial lost 12 pounds.


How do you take Contrave?

Contrave is recommended to be taken twice a day in the morning and evening. 


How long till I lose weight on Contrave?

Peak weight loss is seen at 36 weeks with Contrave.


How does Contrave make you feel?

Common side effects seen with Contrave include stomach upset, nausea, vomiting, headache, dizziness, and insomnia. 


Does Contrave make you poop?

Diarrhea is a common side effect with Contrave.


Related Drugs


Contrave {package insert}. Deerfield, IL: Takeda Pharmaceuticals America, Inc.; 2014.

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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