Aczone (Dapsone)

(℞) Prescription Required

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    Aczone (Dapsone) Dosage and Side Effects

    ACZONE is used to treat acne.  The oral form of the drug is used to treat leprosy (an infectious disease that causes skin lesions and nerve damage), certain lung and brain infections associated with HIV/AIDS, and skin infections.

    Warnings and Precautions

    BEFORE you use ACZONE talk to your doctor or pharmacist if you:

    • are pregnant or planning to be pregnant. Your doctor will decide with you whether the benefit justifies the risk to the foetus.
    • are breast feeding or planning to breast feed. ACZONE is excreted in human breast milk. Your doctor will decide with you whether you should continue breast-feeding or discontinue ACZONE.
    • are less than 12 years of age.
    • are using other products including cosmetics or medicines applied to the skin.
    • have glucose-6-phosphate dehydrogenase (G6PD) deficiency.
    • have a history of slate grey or bluish discoloration of skin, mucous membranes, lips and nail beds due to lack of sufficient oxygen in the blood (methemoglobinemia).

    It is important to let your doctor know about all the medicines you are taking including prescription and nonprescription medicines, vitamins and herbal supplements.

    When using ACZONE avoid contact with, eyes mouth and mucous membranes. If you experience excessive redness or peeling contact your doctor.

    Side Effects

    Like all medicines, ACZONE can cause some side effects, including dryness, redness, oiliness, and peeling. These side effects are usually mild. Call your doctor if you have any side effects that do not go away or bother you.

    The active ingredient of ACZONE (called dapsone) has been associated with blood cell abnormalities, usually when taken orally as a pill. Applying ACZONE on the skin is not expected to put enough dapsone in the blood to cause these abnormalities, and they have not been seen in ACZONE clinical trials. Nonetheless, methemoglobinemia has been reported during use of ACZONE Gel, 5%.

    Interactions with this medication

    Use of benzoyl peroxide together with ACZONE at the same time may cause your skin and facial hair to temporarily turn yellow or orange at the site of application. The use of any other topical medications, including benzoyl peroxide at the same time as ACZONE should be discussed with your doctor or pharmacist.

    Proper Use of this medication

    Usual dose—Adults and children over 12 years of age:

    Be sure to follow your doctor's instructions on how to use ACZONE.

    Use ACZONE once in the morning and once in the evening or as your doctor has prescribed.

    A pea-sized amount of ACZONE will usually be enough to cover the cheeks, chin, and forehead.

    To use ACZONE correctly follow these steps:

    • Wash the areas of your skin where you will apply ACZONE with a mild non-medicated soap. Gently pat your skin dry with a clean towel.
    • Apply a thin layer of ACZONE to the areas of your skin that have acne.
    • Avoid contact with eyes, mouth, and mucous membranes. In case of accidental contact rinse with large amounts of water.
    • Rub the medicine in gently and completely.
    • Make sure to put the cap back on the tube and close it tightly.
    • Wash your hands after applying ACZONE.
    • Do not expect to see an immediate improvement in your acne, but be patient and continue to use your medication as directed.
    • ACZONE has been prescribed by your doctor for you. Do not allow others to use this medication.


    ACZONE is not for oral use. If oral ingestion occurs, seek medical advice or consult a poison control centre.

    Missed dose:

    If an application of ACZONE is missed, it should be applied as soon as possible. This will help to keep a constant amount of medication in the skin. However, if it is almost time for the next application, skip the missed application and go back to the regular schedule. Do not double applications.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.