Ziac (Bisoprolol Fumarate, Hydrochlorothiazide)

(℞) Prescription Required

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Ziac 2.5mg/6.25mg

Product of India
Manufactured by: Merck Sharp & Dohme
*Product image for reference use only.
Ziac is also marketed as Lodoz
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Ziac 2.5mg/6.25mg
Product of India
Manufactured by Merck Sharp & Dohme
Top Brand Choice
Top Generic Choice

Ziac 5mg/6.25mg

Product of India
Manufactured by: Merck Sharp & Dohme
*Product image for reference use only.
Ziac is also marketed as Lodoz
Select Quantity
Ziac 5mg/6.25mg
Product of India
Manufactured by Merck Sharp & Dohme
Select your dosage

Ziac (Bisoprolol Fumarate, Hydrochlorothiazide) Dosage and Side Effects

ZIAC is a combination medicine used to treat high blood pressure (hypertension).

Warnings and Precautions

You should not use this medicine if you are unable to urinate. You should not use ZIAC if you have a serious heart condition such as "sick sinus syndrome" or "AV block," severe heart failure, or slow heartbeats that have caused you to faint.

You should not use this medicine if you are allergic to hydrochlorothiazide or bisoprolol, or if you have:

  • severe or uncontrolled heart failure;
  • slow heartbeats that have caused you to faint;
  • a serious heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree); or
  • if you are unable to urinate.

To make sure ZIAC is safe for you, tell your doctor if you have:

  • congestive heart failure;
  • asthma or other breathing disorder;
  • diabetes;
  • a thyroid disorder;
  • glaucoma;
  • peripheral vascular disease such as Raynaud's syndrome;
  • kidney disease;
  • liver disease (or cirrhosis);
  • lupus;
  • gout; or
  • an allergy to sulfa drugs or penicillin.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

ZIAC can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

ZIAC is not approved for use by anyone younger than 18 years old.

Side Effects

Call your doctor at once if you have:

  • chest pain;
  • fast, slow, or uneven heartbeats;
  • a light-headed feeling, like you might pass out;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • dizziness, spinning sensation;
  • feeling weak or tired;
  • diarrhea, nausea, upset stomach;
  • headache;
  • cough, runny nose; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Interactions with this medication

Avoid drinking alcohol. It may increase your blood levels of bisoprolol.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb ZIAC.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with bisoprolol, especially:

  • colestipol or cholestyramine;
  • insulin or oral diabetes medicine;
  • lithium;
  • sedatives or narcotic medicine;
  • heart or blood pressure medicine--clonidine, digoxin, diltiazem, disopyramide, reserpine, verapamil, and others;
  • NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
  • steroid medicine--prednisone and others.

This list is not complete. Other drugs may interact with bisoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Proper Use of this medication

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use ZIAC.

Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated.

If you are diabetic, check your blood sugar carefully. Taking bisoprolol may make it harder for you to tell when you have low blood sugar. Your insulin or diabetes medication needs may change while you are taking ZIAC. Do not change your medication dose or schedule without your doctor's advice.

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

Do not skip doses or stop using bisoprolol suddenly. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature, away from heat and moisture. Keep the bottle tightly closed when not in use.

Seek emergency medical attention or call the Poison Help line.

Overdose symptoms may include confusion, leg cramps, numbness and tingling, slow heartbeats or fainting.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Other related products

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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