Zaxine (Rifaximin)

This medicine isn't effective for all forms of traveler's diarrhea. Your healthcare provider will decide if ZAXINE is right for you.

Before taking ZAXINE, tell your doctor if you have:

• Diarrhea with fever
• Watery or bloody diarrhea
• Liver disease
• Allergies to any medications

This drug won't treat viral infections such as the common cold or flu.

Call your physician if your symptoms don't improve or worsen after 24 hours of taking ZAXINE.

Antibiotics such as ZAXINE may increase your risk of developing Clostridium difficile-associated diarrhea, a serious form of infectious colitis caused by C. diff bacteria.

Tell your doctor if your diarrhea continues after you stop using ZAXINE.

Take this medicine for the entire amount of time that your doctor prescribes it. Your symptoms might improve before your infection clears.

Don't give ZAXINE to a child who is younger than 12.

Pregnancy and ZAXINE

It's not known whether ZAXINE will harm an unborn baby.

Tell your doctor if you're pregnant or might become pregnant before using this medicine.

It's also uncertain if the drug passes into breast milk or could hurt a breastfeeding baby. You shouldn't breastfeed while taking ZAXINE.

Common Side Effects of ZAXINE

Tell your doctor if any of the following side effects are severe or don't go away:

• Stomach pain or nausea
• Headache
• Dizziness
• Swelling of the hands, feet, or midsection
• Flatulence or gas
• Feeling like your bowel isn't completely empty
• Feeling like you need to empty your bowel urgently

Serious Side Effects of ZAXINE

Tell your doctor immediately if you experience any of the following serious side effects:

• Diarrhea that's watery or bloody
• Fever
• Signs of an allergic reaction, which may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking before taking ZAXINE, especially:

• Antifungal medicines such as Sporanox (itraconazole) or Nizoral (ketoconazole)
• Heart or blood pressure medicines such as Capoten (captopril), Cardizem (diltiazem), Cordarone (amiodarone), Coreg (carvedilol), Covera-HS (verapamil), Multaq (dronedarone), Plendil (felodipine), Quinidex (quinidine), or Ranexa (ranolazine)
• Kaletra (lopinavir and ritonavir)
• Sandimmune (cyclosporine)
• Other antibiotics such as Z-Pak (azithromycin), Biaxin (clarithromycin), or E-Mycin (erythromycin)

You can take Xifaxan with or without food.

Xifaxan Overdose

If you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

Missed Dose of Xifaxan

If you miss a dose of Xifaxan, take it as soon as you remember.

However, skip the missed dose if it's almost time for your next dose.

Don't take extra medicine to make up for a missed dose.