Resolor (Prucalopride)

(℞) Prescription Required - Resolor is also marketed as Resotran

Resolor (Prucalopride) Dosage and Side Effects

Prucalopride belongs to the class of medications called enterokinetic agents. This medication is used by women experiencing chronic (long-term) constipation that is not caused by medications or another medical condition. Prucalopride is used after other laxatives have been tried and have not provided enough relief from constipation.

Proper Use of this medication

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

If there has been no bowel movement after taking prucalopride for 3 or 4 days, contact your doctor. Your doctor may suggest adding a "rescue" laxative to be taken occasionally while you are taking prucalopride.

This medication may be taken with food or on an empty stomach. Try to take it at the same time each day.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Prucalopride should be kept in its original blister packaging to protect it from moisture. Store this medication at room temperature, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • back pain
  • diarrhea
  • dizziness
  • enlargement of abdomen or stomach
  • fatigue
  • headache
  • heartburn
  • gas
  • loss of appetite
  • nausea
  • sinusitis
  • stomach upset
  • tiredness
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abnormal heart rhythms (such as fast or slow heart rate, palpitations)
  • chest pain
  • migraine
  • pounding, rapid heartbeat (palpitations)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • severe diarrhea (watery; may also be bloody) or worsening abdominal pain
  • signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
  • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Warnings and Precautions

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Abnormal heart rhythm: Prucalopride has been shown to cause increased heart rate and may contribute to an irregular heartbeat. If you have a history of irregular heartbeat or ischemic heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Bowel inflammation: This medication may cause a potentially dangerous condition known as ischemic colitis. This occurs when not enough blood is reaching the walls of the colon. Symptoms include abdominal pain; severe, watery diarrhea that may be bloody; or bleeding from the rectum. If you notice these symptoms, stop taking prucalopride and seek immediate medical attention.

Drowsiness/reduced alertness: This medication may cause dizziness or tiredness when you first start to take it. Do not drive, operate machinery, or perform other hazardous tasks until you have determined how this medication affects you.

Liver function: There is very little information about how prucalopride is affected by reduced liver function. If you have liver problems or reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you have severely reduced liver function you may need a lower dose.

Kidney function: Reduced kidney function or kidney disease may cause prucalopride to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

A lower-than-usual dose is recommended for people with severely reduced kidney function. If you have kidney disease that requires dialysis you should not take prucalopride.

Pregnancy: There is not enough information available at this time to determine the safety and effectiveness of using prucalopride during pregnancy. This medication should be avoided by women who are pregnant.

Women of childbearing age who are taking prucalopride should use an effective method of birth control (e.g., birth control pill, condoms) during treatment. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking prucalopride, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children less than 18 years of age.

What other drugs could interact with this medication?

There may be an interaction between prucalopride and any of the following:

  • "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • birth control pills
  • cyclosporine
  • digoxin
  • erythromycin
  • grapefruit juice
  • quinidine
  • verapamil

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Interactions with this medication

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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