Persantine 

Generic equivalent: Dipyridamole

    Persantine (dipyridamole) Dosage and Side Effects

    PERSANTINE dilates the blood vessels of the heart muscle and increases the blood flow to your heart.

    Proper Use of this medication

    Usual dose:

    PERSANTINE ampoules are usually given as an injection by a doctor or nurse.

    Another injection containing the imaging agent is given within 5 minutes of the PERSANTINE injection.

    Overdose:

    In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

    No cases of overdose have been reported in this indication. In case of overdose you may feel warm, flushes, sweating, accelerated pulse, restlessness, feeling of weakness and dizziness, and may have chest pain or difficulty breathing. A drop in blood pressure and fast heart rate might be observed. Your doctor may use another medication (aminophylline) to reverse these symptoms.

    Side Effects

    Like all medicines, PERSANTINE can cause side effects although not everybody gets them.

    A precise estimation of frequency is not possible as the adverse drug reactions did not occur in a clinical trial.

    If you experience dizziness during the test, you should avoid potentially dangerous tasks such as driving or operating machines 24 hours after the test.

    This is not a complete list of side effects. For any unexpected effects while taking PERSANTINE, contact your doctor or pharmacist.

    Warnings and Precautions

    Since this drug may cause sudden death, cardiac arrest and ECG change, it should be only used in a clinical setting with appropriate equipment and under the monitoring of trained health professionals.

    BEFORE you use PERSANTINE talk to your doctor or pharmacist if:

    • You are allergic to dipyridamole or any other ingredient in the drug.
    • You have or ever had any heart problems, such as a recent heart attack (within the last 4 weeks), coronary artery disease, angina (chest pain) at rest, irregular heart beat, heart block (this usually causes a slow heart beat), heart failure or a problem affecting the heart valves.
    • You have low blood pressure.
    • You had a stroke or something called a transient ischemic attack (temporary stroke symptoms lasting less than 24 hours).
    • You have breathing problems such as asthma, shortness of breath or wheezing.
    • You have myasthenia gravis (a rare muscle problem).
    • You are pregnant, likely to become pregnant, or are breast-feeding.

    During the test, reactions similar to exercise-induced stress may occur; therefore your doctor will monitor you. Patients with a history of severe coronary heart disease or history of asthma may be at a greater risk. Abnormal heart beat, chest pain, bronchospasm or severe drop in blood pressure can occur. Your doctor may use another medication (aminophylline and nitroglycerin) to reverse these symptoms.

    Interactions with this medication

    Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines obtained without a prescription and herbal medicines.

    Drugs that may interact with PERSANTINE include: adenosine, other drugs that prevent blood clotting, blood pressure lowering drugs, and cholinesterase inhibitors.

    Tell your doctor about all medication that you are currently taking. Some medication may have to be stopped temporarily 24 hours before the test.

    Theophylline or caffeine-containing drugs or food products and beverages (soft drinks, coffee, tea and chocolates) containing caffeine should be stopped 24 hours before the stress test.

    Other related products

    The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.