Onreltea Gel (Brimonidine)

(℞) Prescription Required - Onreltea Gel is also Marketed as Mirvaso

Onreltea Gel (Brimonidine) Dosage and Side Effects

ONRELTEA is used for the topical skin treatment of facial redness of rosacea in adult patients.

Proper Use of this medication

Always use this medicine exactly as your doctor has told you. Check with your doctor if you are not sure.

ONRELTEA is only intended for use in adults.

Not for oral, ophthalmic, or intravaginal use.

Wash hands before and after use.

As for many people, this product should start to relieve the redness in your face within 30 minutes with maximum effect at about 3 hours. Take this for as long as directed by your doctor. If the product does not improve your symptom within 5 days, contact your doctor.

Usual adult dose:

Apply a small pea-size amount once daily to each of the five areas of the face (i.e., forehead, chin, nose, each cheek) avoiding the eyes and lips. ONRELTEA should be applied smoothly and evenly across all application areas.

Five small pea size amounts, estimated to be no more than 1 g in total weight, is the maximum daily recommended dose. Do not exceed the total daily recommended dose (5 pea size amounts).

If you experience worsening of redness or burning you should stop using ONRELTEA and contact your doctor if needed.

Cosmetics may be applied after the application of ONRELTEA.


In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Side Effects

The most common side effects are:

  • flushing
  • redness
  • itching
  • flushing
  • skin burning sensation

Uncommon side effects are:

  • acne
  • dry mouth
  • feeling cold in hands and feet
  • feeling hot
  • headache
  • nasal congestion
  • skin disease or discomfort
  • tingling or stinging at application site
  • skin irritation
  • warm skin sensation
  • swelling of the eyelid, swelling of the face, urticaria
  • worsening of rosacea
  • (cutaneous) pain
  • rash
  • dry skin

In case of an allergic reaction or severe skin irritation, stop use and contact your doctor immediately.

This is not a complete list of side effects. For any unexpected effects while taking ONRELTEA, contact your doctor or pharmacist.

Warnings and Precautions

ONRELTEA is not recommended in children and adolescents between 2 and 18 years.

Do not use ONRELTEA on irritated skin or open wounds.

Avoid contact with the eyes and mucous membranes such as the mouth and inside of the nose. In case of accidental contact, rinse with water.

BEFORE you use ONRELTEA talk to your doctor or pharmacist if:

  • You are pregnant or planning to become pregnant
  • You are breastfeeding or planning to breastfeed
  • You have heart problems
  • You have or have had in the past kidney or liver problems
  • You have depression, circulatory problems or decreased blood flow of the brain or the heart, blood pressure disorder, circulatory problems or decreased blood flow of the hands, feet or skin, or Sjögren’s syndrome (chronic autoimmune disease in which a person’s white blood cells attack their moisture-producing glands)
  • You have any allergies to this drug or its ingredients or components of the container
  • Worsening of skin redness, flushing or burning feeling of the skin:
  • Some patients experience the return of their redness worse than it was initially. Such worsening of redness usually develops within the first 2 weeks of treatment with ONRELTEA. Generally, it resolves spontaneously after treatment is stopped. The effect should gradually disappear within a few days in most cases.
  • Before you restart the treatment with ONRELTEA, test it on a small area of the face on a day when you can stay at home, at least one day before full re-treatment. If you do not experience worsening of redness or burning, continue with the usual treatment.
  • In case of worsening or unexpected redness, discontinue the treatment and contact your doctor.

Interactions with this medication

As with most medicines, interactions with other drugs are possible. Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines.

No drug interactions studies were done for ONRELTEA.

The following may interact with ONRELTEA:

  • monoamine oxidase (MAO) inhibitors (class of antidepressant) as it may result in hypotension (low blood pressure).
  • anaesthetics, sedatives, opiates, barbiturates or alcohol.
  • medications which can affect the metabolism and uptake of circulating amines, e.g. chlorpromazine, methylphenidate, reserpine.
  • concomitant treatments which may interfere with the activity of ONRELTEA such as oral or transdermal alpha adrenergic receptor agonists (other alpha agonists, e.g. clonidine; so-called alpha blockers or alpha antagonists, e.g. prazosin, isoprenaline which are most often used for treatment of high blood pressure, slow heart rate or asthma).

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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