Nocdurna (Demopressin Acetate)

(℞) Prescription Required

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Nocdurna 25mcg

Product of Canada
Manufactured by: Ferring Inc.
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Nocdurna 25mcg
Product of Canada
Manufactured by Ferring Inc.
Top Brand Choice
Top Generic Choice

Nocdurna 50mcg

Product of Canada
Manufactured by: Ferring Inc.
*Product image for reference use only.
Select Quantity
Nocdurna 50mcg
Product of Canada
Manufactured by Ferring Inc.
Select your dosage

Nocdurna (Desmopressin) Dosage and Side Effects

NOCDURNA is used in the treatment of adults who have to wake up during the night, up to four times, to urinate (pee).

Warnings and Precautions

NOCDURNA can cause too much water to remain in the body resulting in low sodium levels (hyponatremia). Hyponatremia is a serious condition which in severe cases and if not treated can result in death. If you experience symptoms such as unusual headache, dark urine or little amount of urine passed, nausea, vomiting, feeling weak or tired, sleepiness, unexplained weight gain, muscle cramps, contact your doctor immediately.

Fluid intake must be reduced to a minimum from 1 hour before taking NOCDURNA until at least 8 hours after taking NOCDURNA to prevent hyponatremia.

BEFORE you use NOCDURNA talk to your doctor or pharmacist if you:

  • have or have had hyponatremia (low blood sodium levels)
  • have constant thirst or the habit of drinking large amounts of water or liquids
  • have a fever, the flu, an infection, or diarrhea that may affect your body fluid and salts (electrolytes)
  • have any heart disease or high blood pressure
  • have kidney problems
  • have cystic fibrosis
  • have a bladder problem or outlet obstruction
  • are pregnant or planning to become pregnant
  • are breast-feeding
  • have condition that needs to take water pill (diuretic)

Your doctor will ask you to get your blood checked for sodium before starting NOCDURNA, and men aged 65 years and older on NOCDURNA 50 µg should have their serum sodium checked within 4-8 days and after one month after taking NOCDURNA.These blood tests are for your safety.

NOCDURNA tablets have not been studied in children.

Side Effects

Side effects with NOCDURNA include: Common side effects: hyponatremia, dry mouth, diarrhea and headache.

Hyponatremia is a serious side effects with early symptoms include an unusually bad or prolonged headache, confusion, unexplained weight gain, nausea and vomiting, loss of appetite, feeling restless or irritable, feeling weak or tired, sleepiness and muscle cramps. This can become a serious problem and may lead to convulsions and death. If you experience one or more of these symptoms, stop taking this medicine. Tell your doctor immediately or go to the nearest emergency hospital.

Interactions with this medication

Tell your doctor or pharmacist about your other medication, including the ones that you bought without prescription, natural health products. Especially if you are taking any medicines that may increase risk of increased fluid and decreased salt levels such as nonsteroidal anti-inflammatory drugs such as ibuprofen, naproxen, celecoxib (Celebrex).

Proper Use of this medication

You should take NOCDURNA as prescribed by your doctor.

Usual adult dose:

Women: 25 µg once daily at bedtime.

Men: 50 µg once daily at bedtime.

Water or liquid intake must be limited, especially 1 hour before taking NOCDURNA and until at least 8 hours after taking NOCDURNA.

How to take NOCDURNA?

NOCDURNA should be placed under the tongue one hour before bedtime. The tablet disintegrates instantaneously in the mouth without the need for water.

  1. Be sure your hands are dry.
  2. Completely remove the end tab of a blister strip by tearing along the perforations, starting from the corner with the hand symbol.
  3. Now remove one blister from the strip by tearing along the perforations.
  4. Remove the foil on each blister, starting at the corner with the printed arrow, by peeling off the foil in the direction of the arrow. Do not push the tablet through the foil.
  5. Carefully take one NOCDURNA tablet out of its blister.
  6. Place the NOCDURNA tablet under the tongue and allow it to dissolve. Do not chew or swallow the tablet.


Do not take more than prescribed for you. In case of drug overdose, contact your doctor, or a poison control centre, or go to emergency room of the hospital near you immediately, even if there are no symptoms.

Missed dose:

If you miss a dose, skip the missed dose and take the next dose at your regular time. Do not take two (2) doses at the same time. Do not make up for a missed dose.

Other related products

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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