Nerisone Oily Cream (Diflucortolone Validate)

(℞) Prescription Required

Nerisone (Diflucortolone Validate) Usage and Side Effects

NERISONE is used to help relieve the redness, swelling, and itching of certain skin problems for up to 4 weeks.

Proper Use of this medication

NERISONE is for use on the skin only. It is NOT for use in the eyes or on other mucous membranes.

Usual dose:

Use NERISONE once or twice a day for a maximum of 4 weeks. The number of times you use your medicine may be reduced as your skin gets better or your doctor may prescribe a weaker steroid for you to use instead. It is important to not stop using NERISONE suddenly or your skin condition could flare up again. If your condition does not improve within 2-4 weeks of treatment, speak to your doctor or pharmacist.

If you use NERISONE regularly, make sure you talk to your doctor before you stop using it.

How to Apply NERISONE:

  • Apply a thin layer and gently rub in, using only enough to cover the entire affected area.
  • Wash your hands after use unless treating the hands.
  • Excess product should not be returned to the container, since it may cause contamination.
  • If you are also using an emollient (moisturising) preparation allow time for NERISONE to be absorbed after each application before applying the emollient.
  • Your doctor may recommend using a moisturizer as maintenance therapy.
  • Do not use occlusive dressings such as a bandage, or cover the treated areas tightly.

NERISONE should be used for the minimum amount of time required to achieve the desired results, but always use NERISONE exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.


In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Missed dose:

If you forget to use NERISONE, apply it as soon as you remember. If it is close to the time scheduled to apply your next dose, wait and apply your next scheduled dose and then continue as before. Do not apply extra NERISONE to make up for missed doses.

Side Effects

Like all medicines NERISONE can have side effects although not everybody gets them. Side effects will affect your skin and may have an effect on other parts of your body if a sufficient quantity of medicine is absorbed through the skin and enters your blood stream.

If your skin condition gets worse or your skin becomes swollen during treatment you may be allergic to the medicine or need other treatment. Stop using NERISONE and tell your doctor as soon as possible.

The following side effects have been reported in patients using topical corticosteroids:

Common side effects

  • itchy skin
  • skin burning or pain

Very rare side effects

Use of a topical corticosteroid for a long period of time, over a large body surface, or use under an airtight dressing, may cause the following symptoms:

  • increased weight
  • moon face/rounding of the face, obesity
  • skin thinning (this may cause stretch marks), skin softening, skin wrinkling, skin dryness, the appearance of blood vessels under the surface of your skin (telangiectasia), changes to the colour of your skin
  • increased body hair, hair loss/lack of hair growth/damaged looking hair
  • allergic reaction, irritation or pain at the site of application
  • worsening of condition
  • redness, rash or hives, prickly heat rash
  • secondary infection
  • allergic contact dermatitis/dermatitis (a type of eczema)
  • pimples (pustules)
  • steroid withdrawal syndrome (symptoms may include weight loss, fatigue, nausea, diarrhea, and abdominal pain)

If you have psoriasis you may get raised bumps with pus under the skin. This can happen very rarely during or after treatment and is known as pustular psoriasis.

In children also look out for the following symptoms:

  • delayed weight gain
  • slow growth

Other symptoms that may only show in blood tests or when your doctor gives you a medical examination are: decreased hormone cortisol levels in your blood, increased sugar levels in your blood or urine, high blood pressure, cloudy lens in the eye (cataract), increased pressure in the eye (glaucoma), as well as weakening of `the bones through gradual mineral loss (osteoporosis) and additional tests may be needed after your medical examination to confirm whether you have osteoporosis.

Warnings and Precautions

Topical corticosteroids when used over large areas, on sensitive areas such as the face, in skin-fold areas like the armpit and groin, on broken skin, for prolonged periods or under an airtight dressing are more likely to be absorbed into the bloodstream and cause side effects. Apply only enough to cover the affected areas. NERISONE should not be applied over large areas unless advised by a physician.

Only use NERISONE for as long as your doctor recommends.

Inform your doctor if you have previously used corticosteroids.

Before using NERISONE, talk to your doctor or pharmacist if:

  • you are pregnant or planning to become pregnant.
  • you are breastfeeding. If you do use NERISONE when breastfeeding, do not use on your breast area to ensure that the baby does not accidentally get it in their mouth.
  • you have sores in the leg as a result of poor circulation (such as stasis dermatitis).
  • you have problems with your kidney or liver. You may need to use a smaller amount of NERISONE or use it less often.

While using NERISONE, talk to your doctor or pharmacist if:

  • you develop any skin infection
  • you have an allergic reaction
  • you develop troublesome skin irritation
  • you experience skin thinning or softening
  • your condition worsens or does not improve

While using NERISONE:

  • NERISONE should be used with caution on the face, or in skin fold areas, such as the groin or the armpit.
  • Avoid applying NERISONE in or near the eye, or other mucous membranes. In case of contact, wash with water. Absorption may cause increased pressure in the eye (glaucoma), or a cloudy lens in the eye (cataracts).
  • Do not use occlusive dressings such as a bandage, or cover the treated areas tightly.
  • If you are over 65 years of age, use NERISONE with caution. You may need to use a smaller amount of NERISONE or use it less often
  • The skin of children absorbs larger amounts of topical corticosteroids than the skin of adults; and therefore, children may be more likely to develop side effects.
  • Topical corticosteroids may increase the risk of an allergic reaction or an infection if applied near ulcers on the legs.

Interactions with this medication

Some medicines may affect how NERISONE works, or make it more likely that you’ll have side effects. Examples of these medicines include:

  • Ritonavir (for HIV)
  • Itraconazole (for fungal infections)

Tell your doctor or pharmacist about all your other medications, including medicines that you bought without prescription and natural health products.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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