Lamisil Cream (Terbinafine)

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Lamisil Cream 1%

Product of United Kingdom
Manufactured by: GlaxoSmithKline Inc.
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Lamisil Cream 1%
Product of United Kingdom
Manufactured by GlaxoSmithKline Inc.
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Terbinafine Cream 1%

Product of United Kingdom
Manufactured by: UK Various Generics
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Terbinafine Cream 1%
Product of United Kingdom
Manufactured by UK Various Generics
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Lamisil Cream 1%

Product of Canada
Manufactured by: Novo Nordisk
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Lamisil Cream 1%
Product of Canada
Manufactured by Novo Nordisk
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Lamisil (Terbinafine) Dosage and Side Effects

LAMISIL is used to treat fungal infections of skin, fingernails and toenails.

Proper Use of this medication

To help clear up your infection completely, it is very important that you keep taking this medicine for the prescribed treatment period, even if your symptoms begin to clear up or you begin to feel better after a few days. Since fungal infections may be very slow to clear up, stopping your medication too soon can cause the symptoms and the fungal infection to flare up again.

Usual adult dose:

Follow your doctor's instructions carefully. Do not exceed the recommended dosage. If you have the impression that the effect of LAMISIL is too strong or too weak, talk to your doctor or pharmacist.

Oral: LAMISIL tablets:

Adults: 250 mg once daily.

Taking LAMISIL at the same time each day will help you remember when to take your medicine. LAMISIL tablets can be taken on an empty stomach or after a meal.

You can take LAMISIL tablets if you are aged 65 years and over at the same dose as younger adults.

The duration of treatment varies according to the indication and the severity of infection.

Side Effects

LAMISIL tablets:

As with all medicines, some patients taking LAMISIL tablets may experience some unwanted effects (side effects), although not everybody gets them.

The following side effects have been reported with LAMISIL tablets:

Very common (likely to affect more that 1 in every 10 patients): headache, nausea, mild abdominal pain, stomach discomfort after meal (heartburn), diarrhea, swelling or bloating (a feeling of fullness) of the abdomen, loss of appetite, skin rashes (itchy), joint pain and muscle pain.

Common (likely to affect 1 to 10 in every 100 patients): mood disorder (depression), disturbance or loss of sense of taste, dizziness, eye disorder and tiredness. If you suffer dizziness, do not drive or operate machinery.

Uncommon (likely to affect 1 to 10 in every 1000 patients): If you notice abnormal pale skin, mucosal lining or nail beds, unusual tiredness or weakness or breathlessness on exertion (possible signs of a disease that affects the level of red blood cells), anxiety, tingling or numbness and decreased skin sensitivity, increased sensitivity of the skin to sun, noises (e.g. hissing) in ears, fever and weight loss.

Rare (likely to affect less than 1 to 10 in every 10 000 patients): yellow eyes or skin (liver problems) and abnormal liver function test results.

Very rare (likely to affect less than 1 in every 10 000 patients): decrease in certain types of blood cells, lupus (an autoimmune disease), serious skin reactions, allergic reactions, psoriasis-like skin eruptions (rash with silver coloured appearance), worsening of psoriasis, skin rash with flaking or peeling and hair loss.

If you experience smell, taste, visual or hearing disorders or symptoms of depression, then stop using LAMISIL and call your doctor.

If any of the listed side effects affect you severely, discuss this with your doctor.

Other side effects not listed above may also occur in some patients. If you notice any other side effects not mentioned in this leaflet, inform your doctor or pharmacist.

Some side effects could be serious:

  • if you develop fever, shivering, a sore throat or mouth ulcers due to infections and weakness or if you get infections more frequently or
  • if you experience difficulty in breathing, dizziness, swelling mainly of the face and throat, flushing, crampy abdominal pain and loss of consciousness or if you experience symptoms such as joint pain, stiffness, rash, fever or swollen/enlarged lymph nodes (possible signs of severe allergic reactions).
  • if you develop any skin problems such as rash, red skin, blistering of the lips, eyes or mouth, skin peeling, fever.
  • if you experience severe upper stomach pain with radiation to the back (possible signs of pancreas inflammation).
  • if you experience unexplained muscle weakness and pain or dark (red-brown) urine (possible signs of muscle necrosis).

Warnings and Precautions

Serious Warnings and Precautions

LAMISIL (terbinafine hydrochloride) tablets must not be used if you have pre-existing chronic or active liver disease. Serious and life-threatening cases of liver failure, including death, or requiring liver transplant, have been reported in patients with or without pre-existing chronic or active liver disease receiving LAMISIL Tablets.

Stop taking LAMISIL tablets and consult your doctor immediately should you develop jaundice (yellowness of skin and/or eyes or other symptoms). See Table of Serious Side Effects.

Your doctor may order blood tests before you start LAMISIL and during LAMISIL treatment.

Before you use LAMISIL, talk to your doctor if you:

  • have or have had a history of any other medical problems such as liver or kidney problems, blood diseases (e.g. anemia), serious skin reactions, or alcohol abuse
  • if you have or have had liver problems, your doctor may require blood tests before and during LAMISIL treatment to test liver function
  • are allergic to any other medicines (either prescription or non-prescription) or foods
  • are pregnant or intend to become pregnant while using LAMISIL.
  • are breast-feeding; oral LAMISIL is excreted in breast milk. Nursing mothers should avoid topical applications of LAMISIL to the breast and infants should not come into contact with areas treated with topical LAMISIL.

Contact your doctor immediately, while taking LAMISIL, if you develop conditions such as:

  • liver problems with symptoms such as persistent nausea, vomiting, abdominal pain, dark urine, pale stools, fatigue, loss of appetite, yellowing of the skin and eyes
  • serious skin reactions such as blistering or peeling skin, blistering of the lips, eye or mouth, red/inflamed skin, hives, fever (due to skin reactions), rash (due to high white blood cell count-eosinophilia)
  • experience symptoms of lupus erythematosus such as thickened patches of red/silver skin (psoriasis), joint pain, muscle disorder/pain and fever
  • blood disorder with symptoms such as weakness, unusual bleeding, bruising, sore throat or frequent infections

Interactions with this medication

Tablets: Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal medicines, oral contraceptives (birth control pills) and non-prescription medicines. Some other medicines may interact with LAMISIL. These include:

  • some medicines used to treat infectious diseases called antibiotics (e.g. rifampicin),
  • some medicines used to treat mood disorders (some antidepressants such as tricyclic antidepressants, selective serotonine reuptake inhibitors including class 1A, 1B and 1C, monoamine oxidase inhibitors Type B, desipramine),
  • some medicines used to treat irregular heart rhythm (antiarrhythmics (e.g. propafenone, amiodarone),
  • some medicines used to treat high blood pressure (e.g. beta-blockers such as metoprolol),
  • theophylline, a medicine used to relieve bronchospasm in asthma,
  • some medicines used to treat cough (e.g. dextromethorphan),
  • cyclosporine, a medicine used to control your body's immune system (e.g. in order to prevent rejection of transplanted organs),
  • St John's wort [Hypericum perforatum]), a herbal medicine used to treat depression

Some cases of menstrual irregularities and pregnancies have been reported in patients taking LAMISIL concomitantly with oral contraceptives; however, the rate of occurrence appears to be within the background incidence for patients taking oral contraceptives alone.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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