Imbruvica (Ibrutinib)

(℞) Prescription Required

Imbruvica (Ibrutinib) Medication Information


Imbruvica is a kinase inhibitor used to treat mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and Waldenstrom’s macroglobulinemia.


The capsules are available in 140 mg strength. 

Side Effects

The most common side effects of Imbruvica include:

  • Thrombocytopenia
  • Diarrhea
  • Fatigue
  • Anemia
  • Neutropenia
  • Muscle pain
  • Bruising
  • Nausea
  • Rash 

Speak with your doctor or pharmacist for a full list of side effects that applies to you.


Hemorrhage can occur, monitor for bleeding 

Monitor patients for fever and possible infections and seek immediate medical attention if patients appear to have an infection. 

This medication can cause a drop in blood counts, complete blood counts monthly 

This medication can cause heart arrythmias called atrial fibrillation.

Other cancers have occurred in patients, patients should be monitored for the development of additional cancers. 

Tumor Lysis Syndrome (TLS) can occur with this medication, patients that are at risk for TLS (e.g. high tumor burden) should be closely monitored

This medication can harm an unborn baby, and women should not become pregnant is they are taking Imbruvica. 


Common medications that interact with Imbruvica are listed:

  • Clozapine
  • Ketoconazole
  • Rifampin
  • Carbamazepine
  • Phenytoin 
  • Digoxin
  • Fosaprepitant
  • Vaccines

Speak with your doctor for more information on drugs that interact with Imbruvica. 


Store at room temperature (68-77ºF). The original packaging should be used until it is dispensed.   

Pharmacist Tips

  • There is a possibility of bleeding on this medication, and Imbruvica may need to be held prior to dental procedures
  • There is a possibility of serious infections, if you have a fever, weakness, and/or confusion, seek medical attention.
  • Atrial fibrillation has been seen in patients, if you experience lightheadedness, fainting, and/or dizziness, seek medical attention. 
  • If you have persistent diarrhea, contact your doctor.

Imbruvica FAQs

How quickly does Imbruvica work?

Most patients will see clinical response in 3 to 6 months. 


How long can you stay on Imbruvica?

Typically you can stay on Imbruvica indefinitely, as long as you are tolerating the medication and your disease is not progressing.


Does Imbruvica weaken your immune system?

Yes, Imbruvica can weaken your immune system. It is important to monitor yourself for possible infections to seek treatment because your immune system is weaker on this medication. 


Can you drink alcohol on Imbruvica?

Typically it is not recommended to drink while receiving Imbruvica, but you should discuss it with your doctor if you are choosing to drink during treatment.


Does Imbruvica make you tired?

Yes, Imbruvica can cause fatigue and anemia, both of which will make you feel tired. 


Related Drugs

  • Treanda
  • Leukeran
  • Nipent
  • Rituxan
  • Arzerra


Imbruvica {package insert}. Sunnyvale, CA: Janssen Biotech, Inc.; 2015.

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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