Endometrin (Progesterone)

(℞) Prescription Required

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Endometrin 100mg

Product of Australia
Manufactured by: Ferring Inc.
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Endometrin 100mg
Product of Australia
Manufactured by Ferring Inc.
Top Brand Choice
Top Generic Choice

Endometrin 100mg

Product of Canada
Manufactured by: Ferring Inc.
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Endometrin 100mg
Product of Canada
Manufactured by Ferring Inc.
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Endometrin (Progesterone) Dosage and Side Effects

ENDOMETRIN is used as a progesterone supplement in women undergoing treatment for in vitro fertilization (IVF).

Proper Use of this medication

Use ENDOMETRIN exactly as prescribed by your doctor.

Usual dose:

One tablet inserted into the vagina 2 to 3 times a day.

How to use ENDOMETRIN:

  1. Unwrap the applicator.
  2. Put one tablet in the space provided at the end of the applicator. The tablet should fit snugly and not fall out.
  3. While you are standing, sitting, or when lying on your back with your knees bent, gently place the thin end of the applicator well into the vagina.
  4. Push the plunger to release the tablet.
  5. Remove the applicator and throw it away in the trash.


Call your doctor if you use too much ENDOMETRIN, or contact poison control centre.

Missed dose:

If you forget a dose of ENDOMETRIN, take the dose as soon as you remember, but do not use more than your daily dose.

Side Effects

Sex steroids may also increase the risk of vision impairment. Talk to your doctor if you are 35 years of age or older, and smoking to prevent complications. ENDOMETRIN should be stopped and contact your doctor immediately if you experience sudden severe headache, impaired vision and stroke.

The sudden discontinuation of ENDOMETRIN may cause increased anxiety, moodiness and increased risk of seizures. If depression worsens ENDOMETRIN should be discontinued.

Common side effects with ENDOMETRIN include: abdominal pain, nausea, swollen ovaries (ovarian hyperstimulation syndrome), abdominal bloating, headache, uterine cramping, vaginal bleeding, vomiting, urinary infections, constipation and tiredness. A side effect associated with IVF includes post procedural pain such as pain post-oocyte retrieval (pelvic pain after surgery).

Less common side effects include vaginal irritation such as genital itching, vaginal burning sensation, vaginal discomfort and discharge, and swelling of the limbs.

Other reported side effects similar to other drugs containing progesterone include breast tenderness, mood swings, irritability and drowsiness.

Warnings and Precautions

Before starting treatment you and your partner should be assessed by a doctor for causes of infertility. Before using ENDOMETRIN, talk to your doctor if you have or have had the following condition:

  • a history of breast disease (e.g., breast lumps) or a family history of breast cancer or genital track cancer
  • high blood pressure
  • heart or kidney disease
  • history of depression
  • migraine headache
  • a history of seizures/epilepsy
  • diabetes
  • a history of blood clots, heart attack or stroke
  • unusual vaginal bleeding without a known reason
  • a history of liver disease or jaundice
  • breast feeding
  • water retention
  • asthma
  • smoking

Interactions with this medication

Tell your doctor or pharmacist if you are taking, or have been taking, any other medicines, even medicines you buy without a prescription, and natural health products. Certain drugs may interact with progesterone. ENDOMETRIN is not recommended for use with other vaginal products (such as those to treat vaginal yeast infection).

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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