Edecrin (Ethacrynic Acid)

(℞) Prescription Required

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Edecrin 25mg

Product of Australia
Manufactured by: A. Menarini Pharma
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Edecrin 25mg
Product of Australia
Manufactured by A. Menarini Pharma
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Edecrin 25mg

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Manufactured by: Bausch Health Canada
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Edecrin 25mg
Product of Canada
Manufactured by Bausch Health Canada
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Edecrin (Ethacrynic acid) Medication Information

 

Uses

The indication of Edecrin is the treatment of edema when an agent with greater diuretic potential is required despite other commonly used antidiuretics.

Dosage

The oral capsules are available in 25 mg strength.

Side Effects

The most common side effects of Edecrin include:

  • Anorexia
  • Malaise
  • Abdominal pain
  • Nausea
  • Headache
  • Fatigue
  • Fever
  • Chills
  • Acute gout
  • hypoglycemia

For a full list of side effects that apply to you, reach out to your doctor or pharmacist.

Precautions

General Weakness, muscle cramps, paresthesias, thirst, anorexia, and electrolyte abnormalities may occur following diuresis and these may be exacerbated by salt restriction.

Loop diuretics have been shown to increase the excretion of magnesium.

In some patients, NSAIDs can reduce the diuretic and antihypertensive effects of diuretics. Therefore, when Edecrin and NSAIDs are used, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Interactions

Common medications that interact with Edecrin are listed:

  • Lithium 
  • Aminoglycosides
  • Cephalosporins
  • NSAIDs
  • Warfarin 

For more information, do not hesitate to contact your doctor or pharmacist.

Storage

Store at controlled room temperature (77ºF). 

Pharmacist Tips

  • To prevent a rapid or substantial loss of fluid or electrolyte than is indicated or necessary, doses must be carefully regulated.
  • A few patients may require initial and maintenance doses as high as 200 mg twice daily. 

Higher doses, most frequently required in patients with severe, refractory edema, should be tapered up gradually.

  • It is usually possible to reduce the dosage and frequency of administration once the dry weight has been achieved.

Ethacrynic FAQs

Should this be given with food?

Should be taken with food.

 

Can I take this if I am pregnant?

Edecrin should be used during pregnancy only if needed.

 

What is Edecrin used for?

Edecrin is used to treat edema associated with heart failure or ascites.

 

What kind of diuretic is ethacrynic acid?

Edecrin is a loop diuretic

 

Does Edecrin contain sulfa?

Edecrin is the only loop diuretic that does not have a sulfa moiety and is safe for patients with a sulfa allergy

 

What are the side effects of Edecrin?

Common side effects are nausea, vomiting, hypoglycemia, headache, fatigue, and confusion.

 

Related Drugs

Reference:

Edecrin {package insert}. Whitehouse Station, NJ: Merck & Co, Inc.; 1984.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/16092s042,16093s044lbl.pdf

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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