Amitiza (Lubiprostone)

(℞) Prescription Required

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Amitiza 8mcg

Product of United States
Manufactured by: Takeda Pharmaceutical Co.
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Amitiza 8mcg
Product of United States
Manufactured by Takeda Pharmaceutical Co.
Top Brand Choice
Top Generic Choice

Lubiprostone 24mcg

Product of India
Manufactured by: Sun Pharmaceuticals Ltd
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Lubiprostone 24mcg
Product of India
Manufactured by Sun Pharmaceuticals Ltd
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Amitiza (Lubiprostone) Medication Information


Amitiza is a chloride channel activator indicated for the treatment of chronic idiopathic constipation in adults and the treatment of irritable bowel syndrome with constipation in women.


There are oral capsules available in several different strengths:

  • 8 mcg
  • 24 mcg

Side Effects

The most common side effects of Amitiza include:

  • Nausea
  • Diarrhea
  • Headache
  • Abdominal pain
  • Abdominal distension
  • Flatulence

Speak with your doctor or pharmacist for a full list of side effects that applies to you.


Patients taking Amitiza may experience nausea. If this occurs, concomitant administration of food with Amitiza may reduce symptoms of nausea.

Amitiza should not be prescribed to patients that have severe diarrhea. Patients should be aware of the possible occurrence of diarrhea during treatment. Patients should be instructed to inform their physician if severe diarrhea occurs.

Dyspnea has also been reported with this medication. These events have usually been described as a sensation of chest tightness and difficulty taking in a breath, and generally have an acute onset within 30–60 minutes after taking the first dose. They generally resolve within a few hours after taking the dose, but recurrence has been frequently reported with subsequent doses.

In patients with symptoms suggestive of mechanical gastrointestinal obstruction, the treating physician should perform a thorough evaluation to confirm the absence of such an obstruction prior to initiating therapy with Amitiza.


Based on studies, amitiza has a low likelihood of drug-drug interactions.

For a more information speak with your doctor or pharmacist. 


Store at controlled room temperature (77ºF) and protect from extreme temperatures.

Pharmacist Tips

  • Amitiza should be taken twice daily with food and water to reduce potential symptoms of nausea.
  • The capsule should be swallowed whole and should not be broken apart or chewed. 
  • Physicians and patients should periodically assess the need for continued therapy.
  • Patients on treatment who experience severe nausea, diarrhea, or dyspnea should inform their physician. Patients taking Amitiza may experience dyspnea within an hour of the first dose. This symptom generally resolves within 3 hours but may recur with repeat dosing.

Amitiza FAQs

Can I take this with food?

This can be taken with or without food, but to reduce the risk of nausea it is recommended to take it with food and water. 


Can I take this if I am pregnant or breastfeeding?

Based on animal studies, Amitiza may cause fetal harm. Discuss with your doctor if you become or are planning to become pregnant. 

Lactating women should monitor their human milk-fed infants for diarrhea while taking Amitiza.

Related Drugs


Amitiza {package insert}. Deerfield, IL: Takeda Pharmaceuticals America, Inc.; 2012.

PharmD Medical Writer

Author: Dr. Larisa Roybal, PharmD

Dr. Roybal is a board-certified pharmacotherapy specialist who has practiced in both ambulatory and acute care settings. Her pharmacy interests include oncology and general inpatient pharmacy.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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